Literature summary for 3.1.1.4 extracted from

Fonseca-Maldonado, R.; Ferreira, T.L.; Ward, R.J.
The bactericidal effect of human secreted group IID phospholipase A2 results from both hydrolytic and non-hydrolytic activities (2012), Biochimie, 94, 1437-1440.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D49K	mutant retains 30% killing of the Gram-negative bacteria at a concentration of 10 mg/ml compared to wild-type despite the absence of catalytic activity	Homo sapiens
D49K	mutant shows 50% reduced hydrolytic activity against dioleoylphosphatidylcholine:dioleoylphosphatidylcholine liposome membranes and reduced killing of Gram-negative bacteria	Homo sapiens
G30S	mutant shows 50% reduced hydrolytic activity against dioleoylphosphatidylcholine:dioleoylphosphatidylcholine liposome membranes and reduced killing of Gram-negative bacteria	Homo sapiens
H48Q	mutant maintained Ca2+-independent membrane-damaging activity, shows reduced hydrolytic activity against dioleoylphosphatidylcholine:dioleoylphosphatidylcholine liposome membranes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UNK4	-	-

Synonyms

Synonyms	Comment	Organism
group IID secretory phospholipase A2	-	Homo sapiens
PLA2G2D	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	enzyme presents bactericidal and Ca2+-independent liposome membrane-damaging activities. Phospholipid bilayer permeabilization by the enzyme is independent of catalytic activity	Homo sapiens

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Release 2023.1 (January 2023)