Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cardiolipin | cytosolic isoform PLA2beta action on phosphatidylcholine vesicles is activated by anionic phosphoinositides and cardiolipin | Mus musculus | |
cardiolipin | cytosolic isoform PLA2beta action on phosphatidylcholine vesicles is activated by anionic phosphoinositides and cardiolipin | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Mus musculus |
expressed in Sf9 insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arachidonyltrifluoromethyl ketone | - |
Homo sapiens | |
arachidonyltrifluoromethyl ketone | - |
Mus musculus | |
pyrrolidine-1 | isoform cPLA2alpha inhibitor | Homo sapiens | |
pyrrolidine-1 | isoform cPLA2alpha inhibitor | Mus musculus | |
pyrrolidine-2 | isoform cPLA2alpha inhibitor | Homo sapiens | |
pyrrolidine-2 | isoform cPLA2alpha inhibitor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
vesicle | - |
Mus musculus | 31982 | - |
vesicle | - |
Homo sapiens | 31982 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | cytosolic isoform PLA2beta action on phosphatidylcholine vesicles displays a requirement for Ca2+ only in the presence of cardiolipin | Mus musculus | |
Ca2+ | cytosolic isoform PLA2beta action on phosphatidylcholine vesicles displays a requirement for Ca2+ only in the presence of cardiolipin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phospholipids + H2O | Mus musculus | - |
? | - |
? | |
phospholipids + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA resin column chromatography | Mus musculus |
Ni-NTA resin column chromatography | Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000006 | - |
isoform cPLA2delta, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Homo sapiens |
0.000015 | - |
isoform cPLA2epsilon, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Homo sapiens |
0.000021 | - |
isoform cPLA2epsilon, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Homo sapiens |
0.00004 | - |
isoform cPLA2epsilon, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Homo sapiens |
0.00006 | - |
isoform cPLA2delta, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Homo sapiens |
0.000145 | - |
isoform cPLA2epsilon, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Homo sapiens |
0.00021 | - |
isoform cPLA2delta, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Homo sapiens |
0.000245 | - |
isoform cPLA2beta, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Mus musculus |
0.000295 | - |
isoform cPLA2beta, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Mus musculus |
0.0003 | - |
isoform cPLA2gamma, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Homo sapiens |
0.0003 | - |
isoform cPLA2gamma, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Homo sapiens |
0.0011 | - |
isoform cPLA2alpha, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Homo sapiens |
0.00245 | - |
isoform cPLA2zeta, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Mus musculus |
0.0225 | - |
isoform cPLA2delta, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Homo sapiens |
0.05 | - |
isoform cPLA2gamma, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Homo sapiens |
0.058 | - |
isoform cPLA2gamma, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Homo sapiens |
0.06 | - |
isoform cPLA2zeta, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Mus musculus |
0.126 | - |
isoform cPLA2alpha, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Homo sapiens |
0.145 | - |
isoform cPLA2alpha, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Homo sapiens |
0.23 | - |
isoform cPLA2alpha, using 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Homo sapiens |
0.365 | - |
isoform cPLA2beta, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Mus musculus |
0.3695 | - |
isoform cPLA2zeta, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, 0.02 mM Ca2+, at 37°C | Mus musculus |
0.372 | - |
isoform cPLA2zeta, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Mus musculus |
0.381 | - |
isoform cPLA2beta, using 1-palmitoyl-sn-glycero-3-phosphocholine as substrate, in 10 mM MOPS, pH 7.2, 0.5 mM EGTA, 100 mM KCl, 0.5 mg/ml bovine serum albumin, in the absence of Ca2+, at 37°C | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine + H2O | - |
Mus musculus | ? | - |
? | |
1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine + H2O | - |
Homo sapiens | ? | - |
? | |
1-palmitoyl-2-oleoyl-phosphatidylcholine + H2O | - |
Mus musculus | ? | - |
? | |
1-palmitoyl-2-oleoyl-phosphatidylcholine + H2O | - |
Homo sapiens | ? | - |
? | |
1-palmitoyl-2-oleoyl-phosphatidylethanolamine + H2O | - |
Mus musculus | ? | - |
? | |
1-palmitoyl-2-oleoyl-phosphatidylethanolamine + H2O | - |
Homo sapiens | ? | - |
? | |
1-palmitoyl-2-oleoyl-phosphatidylglycerol + H2O | - |
Mus musculus | ? | - |
? | |
1-palmitoyl-2-oleoyl-phosphatidylglycerol + H2O | - |
Homo sapiens | ? | - |
? | |
1-palmitoyl-2-oleoyl-phosphatidylinositol + H2O | - |
Mus musculus | ? | - |
? | |
1-palmitoyl-2-oleoyl-phosphatidylinositol + H2O | - |
Homo sapiens | ? | - |
? | |
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate + H2O | - |
Mus musculus | ? | - |
? | |
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate + H2O | - |
Homo sapiens | ? | - |
? | |
1-palmitoyl-sn-glycero-3-phosphocholine + H2O | - |
Mus musculus | ? | - |
? | |
1-palmitoyl-sn-glycero-3-phosphocholine + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | isoform cPLA2beta shows no activity with 1-palmitoyl-2-oleoyl-phosphatidylcholine | Mus musculus | ? | - |
? | |
additional information | isoform cPLA2gamma shows no activity with 1-palmitoyl-2-oleoyl-phosphatidylcholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate, 1-palmitoyl-2-oleoyl-phosphatidylethanolamine, 1-palmitoyl-2-oleoyl-phosphatidylglycerol, and 1-palmitoyl-2-oleoyl-phosphatidylinositol | Homo sapiens | ? | - |
? | |
phospholipids + H2O | - |
Mus musculus | ? | - |
? | |
phospholipids + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cPLA2alpha | isoform | Mus musculus |
cPLA2alpha | isoform | Homo sapiens |
cPLA2beta | isoform | Mus musculus |
cPLA2beta | isoform | Homo sapiens |
cPLA2delta | isoform | Homo sapiens |
cPLA2epsilon | isoform | Homo sapiens |
cPLA2zeta | isoform | Mus musculus |
group IVB phospholipase A2 | - |
Mus musculus |
group IVB phospholipase A2 | - |
Homo sapiens |