Protein Variants | Comment | Organism |
---|---|---|
C47S | the mutation results in the loss of peroxidase activity but acidic Ca2+-independent phospholipase A2 activity remains intact | Homo sapiens |
S32A | the mutation abolishes acidic Ca2+-independent phospholipase A2 activity while the peroxidase activity remained unaffected | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | not dependent upon Ca2+ | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
x * 25000 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | high levels of expression of 1-CysPrx/aiPLA2 | Homo sapiens | - |
mesothelioma cell | high levels of expression of 1-CysPrx/aiPLA2 | Homo sapiens | - |
squamous cell carcinoma cell | high levels of expression of 1-CysPrx/aiPLA2 | Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 25000 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
1-CysPrx | a dual-function enzyme with peroxidase and acidic Ca2+-independent phospholipase A2 activities, also known as peroxiredoxin VI, non-selenium glutathione peroxidase, LTW4, antioxidant protein 2 (AOP2), Clara cell protein 26 (CC26) and p67phox binding protein | Homo sapiens |
1-cysteine peroxiredoxin | a dual-function enzyme with peroxidase and acidic Ca2+-independent phospholipase A2 activities | Homo sapiens |
acidic Ca2+-independent phospholipase A2 | - |
Homo sapiens |
aiPLA2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the functions of 1-CysPrx/aiPLA2 include the protection of cell membrane phospholipids against oxidative damage (peroxidation) and the metabolism (hydrolysis) of phospholipids, such as those of lung surfactant | Homo sapiens |