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Literature summary for 3.1.1.4 extracted from
- Effect of phospholipase A2 hydrolysis products on calcium oxalate precipitation at lipid interfaces (2010), Langmuir, 26, 4925-4932.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Naja mossambica | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Naja mossambica | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-dipalmitoyl-phosphatidylcholine + H2O | hydrolyzes the sn-2 position of a phospholipid liberating a fatty acid and a lysolipid | Naja mossambica | 1-palmitoyl-glycerophosphorylcholine + palmitic acid | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phospholipase A2 | - |
Naja mossambica |
| PLA2 | - |
Naja mossambica |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | hydrolyzes dipalmitoylphosphatidylcholine monolayers in the presence of a supersaturated calcium oxalate subphase, inducing the rapid and plentiful nucleation of calcium oxalate at the lipid interface. Calcium oxalate crystal growth at a ternary monolayer of dipalmitoylphosphatidylcholine, palmitic acid, and a 22-carbon chain lysophospholipid dramatically increases relative to monolayers of just dipalmitoylphosphatidylcholine | Naja mossambica |
| physiological function | possible link between increased phospholipase activity, which is associated with hyperoxaluria, and calcium oxalate precipitation | Naja mossambica |
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Release 2023.1 (January 2023)
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