Application | Comment | Organism |
---|---|---|
medicine | nPLA treatment protects the cell by anti-apoptotic as well as cell survival mechanisms | Naja sputatrix |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Naja sputatrix | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by gel filtration followed by reverse phase high performance liquid chromatography | Naja sputatrix |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Naja sputatrix | - |
Synonyms | Comment | Organism |
---|---|---|
cPLA2 | - |
Naja sputatrix |
iPLA2 | - |
Naja sputatrix |
neutral anticoagulant secretory phospholipase A2 | - |
Naja sputatrix |
NPLA | - |
Naja sputatrix |
PLA2-1B | - |
Naja sputatrix |
PLA2-2A | - |
Naja sputatrix |
PLA2-2C | - |
Naja sputatrix |
Organism | Comment | Expression |
---|---|---|
Naja sputatrix | nPLA treatment shows a downregulation of endogenous iPLA2 | down |
Naja sputatrix | nPLA treatment shows an upregulation of PLA2-1B, -2A and -2C and cPLA2 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | nPLA reduces infarct volume in rats subjected to focal transient cerebral ischemia and alleviates the neuronal damage in organotypic hippocampal slices subjected to oxygen-glucose deprivation. Staurosporine or oxygen-glucose deprivation mediated apoptotic cell death in astrocytoma cells is reduced by nPLA with a corresponding reduction in caspase 3 activity. Protective effects of nPLA at sub-lethal concentrations of the protein | Naja sputatrix |