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Literature summary for 3.1.1.4 extracted from

  • Armugam, A.; Cher, C.; Lim, K.; Koh, D.; Howells, D.; Jeyaseelan, K.
    A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis (2009), BMC Neurosci., 10, 120.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine nPLA treatment protects the cell by anti-apoptotic as well as cell survival mechanisms Naja sputatrix

Organism

Organism UniProt Comment Textmining
Naja sputatrix
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by gel filtration followed by reverse phase high performance liquid chromatography Naja sputatrix

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Naja sputatrix
-

Synonyms

Synonyms Comment Organism
cPLA2
-
Naja sputatrix
iPLA2
-
Naja sputatrix
neutral anticoagulant secretory phospholipase A2
-
Naja sputatrix
NPLA
-
Naja sputatrix
PLA2-1B
-
Naja sputatrix
PLA2-2A
-
Naja sputatrix
PLA2-2C
-
Naja sputatrix

Expression

Organism Comment Expression
Naja sputatrix nPLA treatment shows a downregulation of endogenous iPLA2 down
Naja sputatrix nPLA treatment shows an upregulation of PLA2-1B, -2A and -2C and cPLA2 up

General Information

General Information Comment Organism
physiological function nPLA reduces infarct volume in rats subjected to focal transient cerebral ischemia and alleviates the neuronal damage in organotypic hippocampal slices subjected to oxygen-glucose deprivation. Staurosporine or oxygen-glucose deprivation mediated apoptotic cell death in astrocytoma cells is reduced by nPLA with a corresponding reduction in caspase 3 activity. Protective effects of nPLA at sub-lethal concentrations of the protein Naja sputatrix