Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-benzotriazole-5-carboxylic acid | 43% metabolic stability in an assay with rat liver microsomes. Thermodynamic solubility is less than 1 microg/ml at pH 7.4 | Homo sapiens | |
1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-benzotriazole-6-carboxylic acid | 44% metabolic stability in an assay with rat liver microsomes. Thermodynamic solubility is 2 microg/ml at pH 7.4 | Homo sapiens | |
1-[3-(4-octylphenoxy)-2-oxopropyl]benzimidazole-5-carboxylic acid | 49% metabolic stability in an assay with rat liver microsomes, possesses the best thermodynamic solubility (22 microg/ml at pH 7.4) | Homo sapiens | |
1-[3-(4-octylphenoxy)-2-oxopropyl]benzimidazole-6-carboxylic acid | 40% metabolic stability in an assay with rat liver microsomes. Thermodynamic solubility is 7 microg/ml at pH 7.4 | Homo sapiens | |
1-[3-(4-octylphenoxy)-2-oxopropyl]indazole-5-carboxylic acid | reveals the highest cPLA2a inhibitory potency, is 7fold more active than the lead 1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid, is the metabolically most stable compound in an assay with rat liver microsomes (64% stability). Thermodynamic solubility is less than 1 microg/ml at pH 7.4 | Homo sapiens | |
1-[3-(4-octylphenoxy)-2-oxopropyl]indazole-6-carboxylic acid | 36% metabolic stability in an assay with rat liver microsomes. Thermodynamic solubility is 5 microg/ml at pH 7.4 | Homo sapiens | |
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid | is 7fold less active than 1-[3-(4-octylphenoxy)-2-oxopropyl]indazole-5-carboxylic acid, is the metabolically most stable compound in an assay with rat liver microsomes (65% stability). Thermodynamic solubility is less than 1 microg/ml at pH 7.4 | Homo sapiens | |
1-[3-(4-octylphenoxy)-2-oxopropyl]indole-6-carboxylic acid | 39% metabolic stability in an assay with rat liver microsomes. Thermodynamic solubility is less than 1 microg/ml at pH 7.4 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
cPLA2alpha | - |
Homo sapiens |
cytosolic phospholipase A2alpha | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000005 | - |
- |
Homo sapiens | 1-[3-(4-octylphenoxy)-2-oxopropyl]indazole-5-carboxylic acid | |
0.000016 | - |
- |
Homo sapiens | 1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-benzotriazole-6-carboxylic acid | |
0.000026 | - |
- |
Homo sapiens | 1-[3-(4-octylphenoxy)-2-oxopropyl]-1H-benzotriazole-5-carboxylic acid | |
0.000026 | - |
- |
Homo sapiens | 1-[3-(4-octylphenoxy)-2-oxopropyl]indazole-6-carboxylic acid | |
0.000035 | - |
- |
Homo sapiens | 1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylic acid | |
0.000085 | - |
- |
Homo sapiens | 1-[3-(4-octylphenoxy)-2-oxopropyl]benzimidazole-6-carboxylic acid | |
0.00015 | - |
- |
Homo sapiens | 1-[3-(4-octylphenoxy)-2-oxopropyl]benzimidazole-5-carboxylic acid | |
0.0011 | - |
- |
Homo sapiens | 1-[3-(4-octylphenoxy)-2-oxopropyl]indole-6-carboxylic acid |