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Literature summary for 3.1.1.4 extracted from

  • Chethankumar, M.; Srinivas, L.
    New biological activity against phospholipase A2 by Turmerin, a protein from Curcuma longa L (2008), Biol. Chem., 389, 299-303.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
PLA2 injected (subcutaneous) into the right hind paw of mice Naja naja

Inhibitors

Inhibitors Comment Organism Structure
turmerin inhibits the enzymatic activity and neutralises the pharmacological properties, such as cytotoxicity, oedema and myotoxicity of multitoxic phospholipase A2 of cobra venom in a dose-dependent manner, at a 1:2.5 molar ratio of PLA2:turmerin Naja naja

Organism

Organism UniProt Comment Textmining
Naja naja
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by gel filtration Naja naja

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Naja naja
-

Synonyms

Synonyms Comment Organism
phospholipase A2
-
Naja naja
PLA2
-
Naja naja

General Information

General Information Comment Organism
physiological function PLA2 induces cytotoxic effect on human peripheral lymphocytes. Increased creatine kinase levels (myonecrosis) in the group of mice treated with PLA2 Naja naja