Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.4 extracted from

  • Choi, Y.A.; Kim, D.K.; Bang, O.S.; Kang, S.S.; Jin, E.J.
    Secretory phospholipase A2 promotes MMP-9-mediated cell death by degrading type I collagen via the ERK pathway at an early stage of chondrogenesis (2010), Biol. Cell, 102, 107-119.
    View publication on PubMed
Search for more literature for 3.1.1.4

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
limb mesenchymal cell Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-palmitoyl-2-linoleoyl-sn-glycerophosphorylethanolamine + H2O
-
 Gallus gallus 1-palmitoyl-glycerophosphorylethanolamine + linoleic acid
-
 ?

Synonyms

Synonyms Comment Organism
secretory phospholipase A2
-
 Gallus gallus
sPLA2
-
 Gallus gallus

Expression

Organism Comment Expression
Gallus gallus secretion of sPLA2 during limb development up

General Information

General Information Comment Organism
physiological function sPLA2 influences the proliferation and/or survival of limb mesenchymal cells. Treatment of wing bud mesenchymal cells with exogenous sPLA2 promotes cell death by activating MMP-9 (matrix metalloproteinase-9) through receptor-mediated signalling and increasing type I collagen degradation. Chondro-inhibitory actions by sPLA2 are prevented by functional blocking of FcRY (chicken yolk sac IgY receptor) and by inhibition of ERK (extracellular-signal-regulated kinase) activity Gallus gallus