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Literature summary for 3.1.1.4 extracted from

  • Figueiredo, M.B.; Genta, F.A.; Garcia, E.S.; Azambuja, P.
    Lipid mediators and vector infection: Trypanosoma rangeli inhibits Rhodnius prolixus hemocyte phagocytosis by modulation of phospholipase A2 and PAF-acetylhydrolase activities (2008), J. Insect Physiol., 54, 1528-1537.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dexamethasone inhibitor of PLA2, phagocytosis of hemocyte monolayers is significantly reduced in cells provided by insects treated with dexamethasone (0.125 mM), when compared to untreated controls or hemocytes taken from insects treated with dexamethasone but that receive inoculation of arachidonic acid or platelet activating factor. Inhibits total PLA2 activity in lysates from hemocytes by 42%. Cell-free hemolymph PLA2 activity is not affected by dexamethasone treatment (slight but not significant inhibition) Rhodnius prolixus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ soluble PLA2 shows Ca+2-dependent and independent fractions, corresponding to 3% or 68% of total activity, respectively Rhodnius prolixus

Organism

Organism UniProt Comment Textmining
Rhodnius prolixus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hemocyte
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Rhodnius prolixus
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hemolymph
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Rhodnius prolixus
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larva
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Rhodnius prolixus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-palmitoyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphocholine + H2O
-
Rhodnius prolixus ?
-
?

Synonyms

Synonyms Comment Organism
Ca+2-independent PLA2
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Rhodnius prolixus
cPLA2
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Rhodnius prolixus
cytosolic PLA2
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Rhodnius prolixus
iPLA2
-
Rhodnius prolixus
phospholipase A2
-
Rhodnius prolixus
PLA2
-
Rhodnius prolixus
secreted PLA2
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Rhodnius prolixus
sPLA2
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Rhodnius prolixus

Expression

Organism Comment Expression
Rhodnius prolixus following oral infection with Trypanosoma rangeli, significant attenuation of PLA2 activities in hemocytes (cPLA2, sPLA2 and iPLA2) in cell-free hemolymph. Trypanosoma rangeli infection inhibits total PLA2 activity in lysates from hemocytes by 39% down
Rhodnius prolixus following oral infection with Trypanosoma rangeli, significant enhancement of sPLA2 activities in cell-free hemolymph up

General Information

General Information Comment Organism
physiological function role of PLA2 in the regulation of arachidonic acid and insect platelet activating factor biosynthesis Rhodnius prolixus