Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(9Z)-9-(hydroxyimino)-9H-fluorene-4-carboxamide | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
1-(9H-fluoren-4-ylcarbonyl)piperidine | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
9-oxo-9H-fluorene-3-carboxamide | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
9H-carbazole-4-carboxamide | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
9H-fluoren-4-ol | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
9H-fluorene-4-carboxamide | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
biphenylene-1-carbonyl chloride | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
methyl 9H-fluorene-4-carboxylate | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
additional information | high-throughput inhibitor screening, overview | Pseudomonas aeruginosa | |
N,N-dimethyl-9H-fluorene-4-carboxamide | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
N-9H-fluoren-2-ylformamide | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
N-9H-fluoren-4-ylacetamide | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
N-phenyl-9H-fluorene-4-carboxamide | inhibition of phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa | |
pseudolipasin A | a specific inhibitor for phospholipase A2 activity of cytotoxin ExoU | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Pseudomonas aeruginosa | exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview | ? | - |
? | |
additional information | Pseudomonas aeruginosa PAK-VL1 | exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas aeruginosa PAK-VL1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview | Pseudomonas aeruginosa | ? | - |
? | |
additional information | exoenzyme U, i.e. ExoU, a potent cytotoxin, is delivered via the type III secretion pathway directly into contacting host cells, once inside the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A2 activity, overview | Pseudomonas aeruginosa PAK-VL1 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytotoxin ExoU | - |
Pseudomonas aeruginosa |
exoenzyme U | - |
Pseudomonas aeruginosa |
ExoU-specific PLA2 | - |
Pseudomonas aeruginosa |
PLA2 | - |
Pseudomonas aeruginosa |