Cloned (Comment) | Organism |
---|---|
chromosomal location at 1G1, phylogenetic tree | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of cytosolic PLA2 null mutant mice, phenotype, e.g. with loss of renal concentration function, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phospholipid + H2O | Mus musculus | the enzyme is essential for production of two classes of lipid mediators, fatty acid metabolites, and lysophospholipid-related lipids, and is involved in the remodeling of membrane phospholipids, physiologic functions, overview | lysophospholipid + fatty acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P47713 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme contains phosphorylation sites at Ser505, Ser515, and Ser727 | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phospholipid + H2O | - |
Mus musculus | lysophospholipid + fatty acid | - |
? | |
phospholipid + H2O | the enzyme is essential for production of two classes of lipid mediators, fatty acid metabolites, and lysophospholipid-related lipids, and is involved in the remodeling of membrane phospholipids, physiologic functions, overview | Mus musculus | lysophospholipid + fatty acid | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 85000-110000, about, SDS-PAGE | Mus musculus |
More | the enzyme contains a catalytic lipase domain and a C2 CaLB domain, domain structure, overview | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
cPLA2 | - |
Mus musculus |
cytosolic phospholipase A2 | - |
Mus musculus |
More | the cytosolic PLA2 belongs to the group IV PLA2s | Mus musculus |