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Literature summary for 3.1.1.4 extracted from

  • Machiah, D.K.; Gowda, T.V.
    Purification of a post-synaptic neurotoxic phospholipase A2 from Naja naja venom and its inhibition by a glycoprotein from Withania somnifera (2006), Biochimie, 88, 701-710.
    View publication on PubMed
Search for more literature for 3.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
p-bromophenacyl bromide loss of both catalytic activity and neurotoxicity Naja naja
Withania somnifera glycoprotein WSG in molar ratio of 1:2, enzyme:WSG, complete inhibition of activity, but not neutralization of toxicity Naja naja

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Naja naja enzymes show post-synaptic neurotoxicity, they are toxic to mice with LD50 of 1.9-2.1 mg/kg body weight ?
-
 ?

Organism

Organism UniProt Comment Textmining
Naja naja
-
 isoforms NN-XI-PLA2, NN-XIa-PLA2
-

Purification (Commentary)

Purification (Comment) Organism
-
 Naja naja

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Naja naja
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
123
-
 isoform NN-XI-PLA2, 37°C Naja naja
138
-
 isoform NN-XIa-PLA2, 37°C Naja naja

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzymes show post-synaptic neurotoxicity, they are toxic to mice with LD50 of 1.9-2.1 mg/kg body weight Naja naja ?
-
 ?
phosphatidylcholine + H2O
-
 Naja naja 1-acylglycerophosphocholine + fatty acid
-
 ?

Synonyms

Synonyms Comment Organism
NN-XI-PLA2
-
 Naja naja
NN-XIa-PLA2
-
 Naja naja