Literature summary for 3.1.1.4 extracted from

Yu, B.Z.; Pan, Y.H.; Janssen, M.J.; Bahnson, B.J.; Jain, M.K.
Kinetic and structural properties of disulfide engineered phospholipase A2: insight into the role of disulfide bonding patterns (2005), Biochemistry, 44, 3369-3379.

Search for more literature for 3.1.1.4

Crystallization (Commentary)

Crystallization (Comment)	Organism
wild-type and mutant A12T/H15D/M20L/E71N, in ligand-free form and in complex with inhibitor MJ33	Sus scrofa

Protein Variants

Protein Variants	Comment	Organism
A12T/H15D/M20L/E71N	catalytic activity similar to wild-type	Sus scrofa

Inhibitors

Inhibitors	Comment	Organism	Structure
1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol	i.e. MJ33	Sus scrofa

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.2	-	phosphatidylcholine	mutant A12T/H15D/M20L/E71N, pH 8.0, 24°C	Sus scrofa
0.2	-	phosphatidylcholine	wild-type, pH 8.0, 24°C	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	P00592	isoform IB PLA	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphatidylcholine + H2O	-	Sus scrofa	1-acylglycerophosphocholine + fatty acid	-	?

Synonyms

Synonyms	Comment	Organism
IB PLA2	-	Sus scrofa

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Release 2023.1 (January 2023)