Cloned (Comment) | Organism |
---|---|
- |
Pandinus imperator |
- |
Pseudonaja textilis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent | Mammalia | |
Ca2+ | dependent | Crotalus atrox | |
Ca2+ | dependent | Exaiptasia diaphana | |
Ca2+ | dependent | Pandinus imperator | |
Ca2+ | dependent | Pseudonaja textilis | |
Ca2+ | dependent | Apis mellifera |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
43000 | - |
44000 Da and 43000 Da | Exaiptasia diaphana |
44000 | - |
44000 Da and 43000 Da | Exaiptasia diaphana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mammalia | role in the digestion of prey, neurotoxic, myotoxic, cardiotoxic and cytotoxic activities, can have convulsant, hypotensive and proinflammatory effects, can affect blood coagulation and platelet aggregation, some forms can induce cell proliferation, cell migration and antibacterial activity. Mechanism of action can involve: the intrinsic catalytic activity of vPLA2, i.e. its ability to release potent biologically active fatty acids and lysophospholipids from membrane lipids, the interfacial binding to the membrane lipid bilayer which, without any phospholipid hydrolysis, may affect cellular functions by perturbing cellular membranes, and the binding to specific proteins located at the cell surface | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Apis mellifera | P00630 | bee | - |
Crotalus atrox | - |
- |
- |
Exaiptasia diaphana | - |
sea anemone | - |
Mammalia | - |
- |
- |
Pandinus imperator | - |
scorpion | - |
Pseudonaja textilis | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | enzyme has an uncleaved propeptide sequence with is catalytically inactive | Pseudonaja textilis |
Purification (Comment) | Organism |
---|---|
- |
Exaiptasia diaphana |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Mammalia | - |
venom | - |
Crotalus atrox | - |
venom | - |
Exaiptasia diaphana | - |
venom | - |
Pandinus imperator | - |
venom | - |
Pseudonaja textilis | - |
venom | - |
Apis mellifera | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | role in the digestion of prey, neurotoxic, myotoxic, cardiotoxic and cytotoxic activities, can have convulsant, hypotensive and proinflammatory effects, can affect blood coagulation and platelet aggregation, some forms can induce cell proliferation, cell migration and antibacterial activity. Mechanism of action can involve: the intrinsic catalytic activity of vPLA2, i.e. its ability to release potent biologically active fatty acids and lysophospholipids from membrane lipids, the interfacial binding to the membrane lipid bilayer which, without any phospholipid hydrolysis, may affect cellular functions by perturbing cellular membranes, and the binding to specific proteins located at the cell surface | Mammalia | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | homodimer | Crotalus atrox |
Synonyms | Comment | Organism |
---|---|---|
imperatoxin | - |
Pandinus imperator |
notexinII-1 | - |
Mammalia |
phospholipin | - |
Pandinus imperator |
taipoxin | - |
Mammalia |
textilotoxin | - |
Pseudonaja textilis |