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Literature summary for 3.1.1.34 extracted from

  • Fu, Z.; Abou-Samra, A.B.; Zhang, R.
    A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase (2015), Sci. Rep., 5, 18502 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.34

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
triacylglycerol + H2O Mus musculus
-
 diacylglycerol + a carboxylate
-
 ?
triacylglycerol + H2O Mus musculus BALB/c
-
 diacylglycerol + a carboxylate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P11152
-
-
Mus musculus BALB/c P11152
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac muscle
-
 Mus musculus
-
heart
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-
white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
triacylglycerol + H2O
-
 Mus musculus diacylglycerol + a carboxylate
-
 ?
triacylglycerol + H2O
-
 Mus musculus BALB/c diacylglycerol + a carboxylate
-
 ?

Synonyms

Synonyms Comment Organism
LPL
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus lipasin suppresses the activity of LPL specifically in cardiac and skeletal muscles down

General Information

General Information Comment Organism
physiological function lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase. Lipasin/Angptl8 is a feeding-induced hepatokine that regulates triglyceride (TAG) metabolism. Lipasin-deficient mice exhibit elevated postprandial activity of LPL in the heart and skeletal muscle, but not in white adipose tissue, suggesting that lipasin suppresses the activity of LPL specifically in cardiac and skeletal muscles. During fasting, LPL activity is upregulated in the heart and skeletal muscle, which, in turn, take up fatty acids for energy production. In the fed state, LPL activity is upregulated in white adipose tissue, which, in turn, takes up fatty acids for storage Mus musculus