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Literature summary for 3.1.1.34 extracted from

  • Lookene, A.; Zhang, L.; Tougu, V.; Olivecrona, G.
    1,1'-bis(anilino)-4-,4'-bis(naphtalene)-8,8'-disulfonate acts as an inhibitor of lipoprotein lipase and competes for binding with apolipoprotein CII (2003), J. Biol. Chem., 278, 37183-37194.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
apoprotein C II
-
Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 0.01-0.015 mM, almost complete inhibition of tributyrin and tripropionin hydrolysis, competes for binding with apoprotein CII, inhibition is prevented or restored by apoprotein CII Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
triacylglycerol + H2O Bos taurus
-
diacylglycerol + a carboxylate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-nitrophenyl butyrate + H2O
-
Bos taurus p-nitrophenol + butanoate
-
?
triacetin + H2O
-
Bos taurus acetate + diacetin
-
?
triacylglycerol + H2O
-
Bos taurus diacylglycerol + a carboxylate
-
?
tributyrin + H2O
-
Bos taurus butanoate + dibutyrin
-
?
tricaprylin + H2O
-
Bos taurus capric acid + dicaprylin
-
?
triolein + H2O
-
Bos taurus oleate + diolein
-
?
tripropionin + H2O
-
Bos taurus propionate + dipropionin
-
?

Synonyms

Synonyms Comment Organism
LPL
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00004
-
1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of p-nitrophenyl butyrate Bos taurus
0.00028
-
1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of tripropionin Bos taurus
0.00038
-
1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of tributyrin Bos taurus
0.0017
-
1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of tricaprylin Bos taurus
0.0031
-
1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of triacetin Bos taurus
0.0047
-
1,1'-bis(anilino)-4-,4'-bis(naphthalen)-8,8'-disulfonate 25°C, pH 8.5, hydrolysis of triolein Bos taurus