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Literature summary for 3.1.1.32 extracted from

  • Imae, R.; Inoue, T.; Kimura, M.; Kanamori, T.; Tomioka, N.H.; Kage-Nakadai, E.; Mitani, S.; Arai, H.
    Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol (2010), Mol. Biol. Cell, 21, 3114-3124.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.32

Cloned(Commentary)

Cloned (Comment) Organism
expression of IPLA-1 in HEK-293 cells Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information acl-8 acl-9 acl-10 triple mutations cause misorientation of seam cell divisions similar to that observed in ipla-1 mutants Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
intracellular
-
 Caenorhabditis elegans 5622
-

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant IPLA-1 from HEK-293 cells Caenorhabditis elegans

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with phosphatidylethanolamine and phosphatidic acid by intracellular phospholipase A1 Caenorhabditis elegans ?
-
 ?
phosphatidylcholine + H2O intracellular phospholipase A1 Caenorhabditis elegans lysophosphatidylcholine + fatty acid
-
 ?
phosphatidylinositol + H2O intracellular phospholipase A1 recognizes the sn-1 position of phosphatidylinositol as its substrate, recombinant IPLA-1 hydrolyzes a fatty acid attached to phosphatidylinositol Caenorhabditis elegans ?
-
 ?
phosphatidylserine + H2O intracellular phospholipase A1 Caenorhabditis elegans lysophosphatidylserine + fatty acid
-
 ?

Synonyms

Synonyms Comment Organism
intracellular phospholipase A1
-
 Caenorhabditis elegans
IPLA-1
-
 Caenorhabditis elegans

General Information

General Information Comment Organism
malfunction Because orientation of seam cell division is randomized relative to the A-P axis in ipla-1 mutants, ipla-1 mutants exhibit aberrant orientation of seam cell divisions. Acl-8 acl-9 acl-10 triple mutations also cause misorientation of seam cell divisions similar to that observed in ipla-1 mutants Caenorhabditis elegans
metabolism intracellular phospholipase A1 and acyltransferase are involved in Caenorhabditis elegans stem cell divisions Caenorhabditis elegans
physiological function intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol Caenorhabditis elegans