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Literature summary for 3.1.1.31 extracted from
- Characterization of Arabidopsis 6-phosphogluconolactonase T-DNA insertion mutants reveals an essential role for the oxidative section of the plastidic pentose phosphate pathway in plant growth and development (2009), Plant Cell Physiol., 50, 1277-1291.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| PCR product cloned into the corresponding sites of the vector pGEX-4T-1 and then introduced into Escherichia coli. Constructs (35S:DELTANTpgl3-GFP and 35S:pgl3 DELTASKL-GFP) together with the 35S:PGL3-GFP construct transformed into the pgl3 background. Escherichia coli cells expressing GST-PGL3 and GST-pgl3 mutants | Arabidopsis thaliana |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D150A | displays pgl3 morphology, does not complement the pgl3 phenotypes | Arabidopsis thaliana |
| D150A/D231A/H233A | displays pgl3 morphology, does not complement the pgl3 phenotypes | Arabidopsis thaliana |
| D231A/H233A | displays pgl3 morphology, does not complement the pgl3 phenotypes | Arabidopsis thaliana |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| chloroplast | - |
Arabidopsis thaliana | 9507 | - |
| cytosol | - |
Arabidopsis thaliana | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | Q84WW2 | - |
- |
| Arabidopsis thaliana | Q8LEV7 | - |
- |
| Arabidopsis thaliana | Q8LG70 | - |
- |
| Arabidopsis thaliana | Q9FIN1 | - |
- |
| Arabidopsis thaliana | Q9LMX8 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Arabidopsis thaliana | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-phosphogluconolactonase | - |
Arabidopsis thaliana |
| 6PGL | - |
Arabidopsis thaliana |
| PGL1 | - |
Arabidopsis thaliana |
| PGL2 | - |
Arabidopsis thaliana |
| PGL3 | - |
Arabidopsis thaliana |
| PGL4 | - |
Arabidopsis thaliana |
| PGL5 | - |
Arabidopsis thaliana |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | pgl3 mutation knocks out most of the 6PGL activity. Knockdown of PGL3 leads to a dramatic decrease in plant size, a significant increase in total glucose-6-phosphate dehydrogenase activity and a marked decrease in cellular redox potential. A wild-type PGL3-GFP transgene complements all phenotypes caused by the pgl3 mutation. Plastidic localization and enzymatic activity are required for PGL3 to complement the pgl3 mutant phenotypes. Pgl3 mutation exhibits constitutive pathogenesis-related gene expression and enhanced resistance to Pseudomonas syringae pv. maculicola ES4326 and Hyaloperonospora arabidopsidis Noco2. The pgl3 mutation activates NPR1- and SID2/EDS16/ICS1-dependent defense signaling | Arabidopsis thaliana |
| physiological function | PGL1 is dispensable for plant growth and development | Arabidopsis thaliana |
| physiological function | PGL2 is dispensable for plant growth and development | Arabidopsis thaliana |
| physiological function | PGL3 is the major contributor to total 6PGL activity. PGL3 is essential for plant growth and development. Plastidic localization and 6PGL activity of the PGL3 protein are essential for complementing all pgl3 phenotypes, indicating that the oxidative section of the plastidic pentose phosphate pathway is required for plant normal growth and development. PGL3 may function downstream of salicylic acid | Arabidopsis thaliana |
| physiological function | PGL5 is dispensable for plant growth and development | Arabidopsis thaliana |
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