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Literature summary for 3.1.1.3 extracted from

  • Goodman, K.B.; Bury, M.J.; Cheung, M.; Cichy-Knight, M.A.; Dowdell, S.E.; Dunn, A.K.; Lee, D.; Lieby, J.A.; Moore, M.L.; Scherzer, D.A.; Sha, D.; Suarez, D.P.; Murphy, D.J.; Harpel, M.R.; Manas, E.S.; McNulty, D.E.; Annan, R.S.; Matico, R.E.; Schwartz, B.K.; Trill, J.J.; Sweitzer, T.D.; Wang, D.Y.; Keller, P.M.; Krawie, K.r.a.w.i.e.c.
    Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors (2009), Bioorg. Med. Chem. Lett., 19, 27-30.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(2-chlorophenyl)-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
-
Mus musculus
1-(4-chlorophenyl)-1-methyl-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
-
Mus musculus
1-(4-chlorophenyl)-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
-
Mus musculus
1-(4-methoxyphenyl)-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
-
Mus musculus
1-(diphenylmethyl)-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
-
Mus musculus
1-benzyl-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
-
Mus musculus
1-methyl-1-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]-3-phenylurea
-
Mus musculus
1-methyl-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]-1-phenylurea
-
Mus musculus
1-phenyl-3-[5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
-
Mus musculus
1-[1,2-dimethyl-5-(piperidin-1-ylsulfonyl)-1H-pyrrol-3-yl]-3-phenylurea
-
Mus musculus
1-[1-methyl-3-(piperidin-1-ylsulfonyl)-1H-pyrazol-5-yl]-3-phenylurea
-
Mus musculus
1-[2,4-dimethyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]-3-phenylurea
-
Mus musculus
1-[2-methyl-4-(morpholin-4-ylsulfonyl)phenyl]-3-phenylurea
-
Mus musculus
1-[2-methyl-5-(morpholin-4-ylsulfonyl)furan-3-yl]-3-phenylurea
-
Mus musculus
1-[2-methyl-5-(piperidin-1-ylsulfonyl)-1H-pyrrol-3-yl]-3-phenylurea
-
Mus musculus
1-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]-3-[(1S)-1-phenylethyl]urea
-
Mus musculus
1-[2-methyl-5-[(4-methylpiperazin-1-yl)sulfonyl]furan-3-yl]-3-phenylurea
-
Mus musculus
1-[2-methyl-6-(piperidin-1-ylsulfonyl)pyridin-3-yl]-3-phenylurea
-
Mus musculus
2-methyl-N-phenyl-5-(piperidin-1-ylsulfonyl)furan-3-carboxamide
-
Mus musculus
5-methyl-N-phenyl-4-[(phenylcarbamoyl)amino]furan-2-sulfonamide
-
Mus musculus
N,N,5-trimethyl-4-[(phenylcarbamoyl)amino]furan-2-sulfonamide
-
Mus musculus
N-(2-methoxyethyl)-N,5-dimethyl-4-[(phenylcarbamoyl)amino]furan-2-sulfonamide
-
Mus musculus
sulfonylfuran urea potent and non-selective inhibitor of endothelial lipase Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
endothelial lipase
-
Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00006
-
-
Mus musculus 1-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]-3-[(1S)-1-phenylethyl]urea
0.00013
-
-
Mus musculus 1-(2-chlorophenyl)-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
0.00013
-
-
Mus musculus 1-(4-methoxyphenyl)-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
0.00013
-
-
Mus musculus 1-[2-methyl-5-(morpholin-4-ylsulfonyl)furan-3-yl]-3-phenylurea
0.00013
-
-
Mus musculus sulfonylfuran urea
0.00016
-
-
Mus musculus 1-(diphenylmethyl)-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
0.0002
-
-
Mus musculus 1-(4-chlorophenyl)-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
0.00025
-
-
Mus musculus N-(2-methoxyethyl)-N,5-dimethyl-4-[(phenylcarbamoyl)amino]furan-2-sulfonamide
0.0003
-
-
Mus musculus N,N,5-trimethyl-4-[(phenylcarbamoyl)amino]furan-2-sulfonamide
0.001
-
-
Mus musculus 5-methyl-N-phenyl-4-[(phenylcarbamoyl)amino]furan-2-sulfonamide
0.0013
-
-
Mus musculus 1-[2-methyl-5-[(4-methylpiperazin-1-yl)sulfonyl]furan-3-yl]-3-phenylurea
0.0025
-
-
Mus musculus 1-phenyl-3-[5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
0.025
-
-
Mus musculus 1-methyl-1-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]-3-phenylurea
0.05
-
IC50 above 0.05 mM Mus musculus 1-(4-chlorophenyl)-1-methyl-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
0.05
-
IC50 above 0.05 mM Mus musculus 1-[1,2-dimethyl-5-(piperidin-1-ylsulfonyl)-1H-pyrrol-3-yl]-3-phenylurea
0.05
-
IC50 above 0.05 mM Mus musculus 1-[1-methyl-3-(piperidin-1-ylsulfonyl)-1H-pyrazol-5-yl]-3-phenylurea
0.05
-
IC50 above 0.05 mM Mus musculus 1-[2,4-dimethyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]-3-phenylurea
0.05
-
IC50 above 0.05 mM Mus musculus 1-[2-methyl-4-(morpholin-4-ylsulfonyl)phenyl]-3-phenylurea
0.05
-
IC50 above 0.05 mM Mus musculus 1-[2-methyl-5-(piperidin-1-ylsulfonyl)-1H-pyrrol-3-yl]-3-phenylurea
0.05
-
IC50 above 0.05 mM Mus musculus 1-[2-methyl-6-(piperidin-1-ylsulfonyl)pyridin-3-yl]-3-phenylurea
0.05
-
IC50 above 0.05 mM Mus musculus 1-benzyl-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]urea
0.05
-
IC50 above 0.05 mM Mus musculus 1-methyl-3-[2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl]-1-phenylurea
0.05
-
IC50 above 0.05 mM Mus musculus 2-methyl-N-phenyl-5-(piperidin-1-ylsulfonyl)furan-3-carboxamide