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Literature summary for 3.1.1.29 extracted from

  • Goedeke, J.; Pustelny, C.; Haeussler, S.
    Recycling of peptidyl-tRNAs by peptidyl-tRNA hydrolase counteracts azithromycin-mediated effects on Pseudomonas aeruginosa (2013), Antimicrob. Agents Chemother., 57, 1617-1624.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-substituted aminoacyl-tRNA + H2O Pseudomonas aeruginosa
-
N-substituted amino acid + tRNA
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-substituted aminoacyl-tRNA + H2O
-
Pseudomonas aeruginosa N-substituted amino acid + tRNA
-
?

Synonyms

Synonyms Comment Organism
PA4672
-
Pseudomonas aeruginosa
peptidyl-tRNA hydrolase
-
Pseudomonas aeruginosa
PTH
-
Pseudomonas aeruginosa

General Information

General Information Comment Organism
physiological function azithromycin stationary-phase killing is decreased in enzyme-overexpressing Pseudomonas aeruginosa cells. Overexpressing the enzyme counteracts the azithromycin-mediated effect on rhamnolipid production and partially restores swarming activity Pseudomonas aeruginosa