Cloned (Comment) | Organism |
---|---|
expressed as GST-fusion protein in Escherichia coli Rosetta pLysS (GST later cleaved), or in human HEK293T cells as FLAG-tagged protein | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | truncated ICT1 form lacking the N-terminal 29 residues leads to reduction in mitochondrial protein synthesis, a mutation of the GGQ domain of ICT1 by site-directed mutagenesis causes loss of cell viability | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | mitochondiral ribosome | Homo sapiens | 5739 | - |
ribosome | mitochondiral ribosome | Homo sapiens | 5840 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
23000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14197 | colon carcinoma HeLa cells | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ICT1 | immature colon carcinoma transcript-1 with PTH activity | Homo sapiens |
peptidyl-tRNA hydrolase | - |
Homo sapiens |
PTH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | ICT1 is a member of the large mitoribosomal subunit: it behaves as an integral member of the 39S mt-LSU and a component of the intact 55S monosome | Homo sapiens |