Crystallization (Comment) | Organism |
---|---|
purified recombinant enzyme, X-ray diffraction structure determination and analysis at 1.98 A, 2.35 A, and 2.49 A resolution, molecular replacement | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidyl-tRNA + H2O | Mycobacterium tuberculosis | peptidyl-tRNA hydrolase cleaves the ester bond between tRNA and the attached peptide in peptidyl-tRNA in order to avoid the toxicity resulting from its accumulation and to free the tRNA available for further rounds in protein synthesis | peptide + tRNA | - |
? | |
peptidyl-tRNA + H2O | Mycobacterium tuberculosis H37Rv | peptidyl-tRNA hydrolase cleaves the ester bond between tRNA and the attached peptide in peptidyl-tRNA in order to avoid the toxicity resulting from its accumulation and to free the tRNA available for further rounds in protein synthesis | peptide + tRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WHN7 | gene pth, orf Rv1014c | - |
Mycobacterium tuberculosis H37Rv | P9WHN7 | gene pth, orf Rv1014c | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA | structure-function relationship, residues Asp95 and His115 are involved in catalysis, overview | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidyl-tRNA + H2O | peptidyl-tRNA hydrolase cleaves the ester bond between tRNA and the attached peptide in peptidyl-tRNA in order to avoid the toxicity resulting from its accumulation and to free the tRNA available for further rounds in protein synthesis | Mycobacterium tuberculosis | peptide + tRNA | - |
? | |
peptidyl-tRNA + H2O | peptidyl-tRNA hydrolase cleaves the ester bond between tRNA and the attached peptide in peptidyl-tRNA in order to avoid the toxicity resulting from its accumulation and to free the tRNA available for further rounds in protein synthesis | Mycobacterium tuberculosis H37Rv | peptide + tRNA | - |
? | |
peptidyl-tRNAL + H2O | cleavage of the ester bond between tRNA and the attached peptide in peptidyl-tRNA, substrate binding channel structure, overview | Mycobacterium tuberculosis | peptide + tRNA | - |
? | |
peptidyl-tRNAL + H2O | cleavage of the ester bond between tRNA and the attached peptide in peptidyl-tRNA, substrate binding channel structure, overview | Mycobacterium tuberculosis H37Rv | peptide + tRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peptidyl-tRNA hydrolase | - |
Mycobacterium tuberculosis |
PTH | - |
Mycobacterium tuberculosis |