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Literature summary for 3.1.1.28 extracted from

  • Meadows, J.A.; Wargo, M.J.
    Characterization of Pseudomonas aeruginosa growth on O-acylcarnitines and identification of a short-chain acylcarnitine hydrolase (2013), Appl. Environ. Microbiol., 79, 3355-3363.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli T7 Express cells Pseudomonas aeruginosa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Pseudomonas aeruginosa 5737
-

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9HTI0
-
-

Purification (Commentary)

Purification (Comment) Organism
cobalt affinity column chromatography Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-L-carnitine + H2O
-
 Pseudomonas aeruginosa acetate + L-carnitine
-
 ?
butyryl-L-carnitine + H2O
-
 Pseudomonas aeruginosa butyrate + L-carnitine
-
 ?
additional information no activity with D-acetylcarnitine, acetylcholine, and octanoyl-L-carnitine Pseudomonas aeruginosa ?
-
 ?

Synonyms

Synonyms Comment Organism
HocS hydrolase of O-acylcarnitine, short chains Pseudomonas aeruginosa
L-enantiomer-specific short-chain acylcarnitine hydrolase
-
 Pseudomonas aeruginosa
PA5384 locus name Pseudomonas aeruginosa

General Information

General Information Comment Organism
physiological function the enzyme is required for growth on acetylcarnitine and is important for osmoprotection and induction of the virulence factor PlcH Pseudomonas aeruginosa