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Literature summary for 3.1.1.25 extracted from

  • Tripathy, R.K.; Aggarwal, G.; Bajaj, P.; Kathuria, D.; Bharatam, P.V.; Pande, A.H.
    Towards understanding the catalytic mechanism of human paraoxonase 1 experimental and in silico mutagenesis studies (2017), Appl. Biochem. Biotechnol., 182, 1642-1662 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R180T the mutant retains a partial hydrolyzing activity against homocysteinethiolactone, whereas the delta-valerolactone-hydrolyzing activity is completely abolished Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxyquinoline specific inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Q-Sepharose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
delta valerolactone + H2O
-
Homo sapiens 5-hydroxypentanoic acid
-
?
homocysteinethiolactone + H2O
-
Homo sapiens homocysteine
-
?
N-oxodecanoyl-DL-homoserine lactone + H2O
-
Homo sapiens N-(3-oxodecanoyl)homoserine
-
?

Subunits

Subunits Comment Organism
? x * 45000, SDS-PAGE Homo sapiens