Literature summary for 3.1.1.25 extracted from

Rock, W.; Rosenblat, M.; Miller-Lotan, R.; Levy, A.P.; Elias, M.; Aviram, M.
Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities (2008), J. Agric. Food Chem., 56, 8704-8713.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	pomegranate juice and pomegranate polyphenol extract (from variety Wonderful) consumption contributes to PON1 stabilization, increased association with high density lipoprotein, and enhanced catalytic activity	Homo sapiens

General Stability

General Stability	Organism
association of paraoxonase 1 with high-density lipoprotein stabilizes the enzyme	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
nitrilotriacetic acid	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P27169	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dihydrocoumarin + H2O	weak activity	Homo sapiens	3-(2-hydroxyphenyl)-propionic acid	-	?
additional information	contains arylesterase, paraoxonase, and lactonase activities	Homo sapiens	?	-	?
thiobutyl butyrolactone + H2O	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)