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Literature summary for 3.1.1.25 extracted from

  • Lu, H.; Zhu, J.; Zang, Y.; Ze, Y.; Qin, J.
    Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product (2005), Biochem. Pharmacol., 70, 1019-1025.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression of PON3 in Spodoptera frugiperda Sf9 cells using the baculovirus expression system Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
EDTA 0.005-0.01 mM Homo sapiens
PMSF 1 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.84
-
 dihydrocoumarin pH 8.0, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15166
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrocoumarin + H2O
-
 Homo sapiens 3-(2-hydroxyphenyl)propanoic acid
-
 ?
additional information the enzyme can delay and inhibit low-density lipoprotein oxidation in a dose-dependent manner Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5 10 pH 5.0: about 55% of maximal activity, pH 10.0: about 35% of maximal activity Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
4.5 9 lactonase activity is quite stable Homo sapiens