Literature summary for 3.1.1.23 extracted from

Xiang, W.; Shi, R.; Kang, X.; Zhang, X.; Chen, P.; Zhang, L.; Hou, A.; Wang, R.; Zhao, Y.; Zhao, K.; Liu, Y.; Ma, Y.; Luo, H.; Shang, S.; Zhang, J.; He, F.; Yu, S.; Gan, L.; Shi, C.; Li, Y.; Yang, W.; Liang, H.; Miao, H.
Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression (2018), Nat. Commun., 9, 2574 .

Search for more literature for 3.1.1.23

Application

Application	Comment	Organism
diagnostics	enzyme MGLL in tumor-associated macrophages predicts the survival of colorectal cancer patients	Homo sapiens
medicine	expression of macrophage MGLL is decreased in cancer tissues and positively correlated with the survival of cancer patients. Monoacylglycerol lipase is a switch for CB2/TLR4-dependent macrophage activation and a potential target for cancer therapy. Modulation of MGLL-CB2 axis in macrophages might be a promising strategy for cancer treatment	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	the transgene of human MGLL in macrophages largely prolonges the survival of MC-38 tumor-bearing mice	Homo sapiens
additional information	the transgene of human MGLL in macrophages largely prolonges the survival of MC-38 tumor-bearing mice, employment of Rag1 knockout mouse model with lymphocyte deficiency, the antitumor effect of macrophage MGLL is largely attenuated in Rag1 knockout mouse, incidence of lung metastasis in MC-38 tumors is 100%, regardless of wild-type or TgMGLL KO mice, and cytokine expression does not differ between the wild-type and TgMGLL KO macrophages from the spleens of MC-38 tumor-bearing mice. Bone marrow-derived macrophages with the MGLL transgene express much higher levels of IL-1beta and TNFalpha in response to IFNgamma and LPS stimulation and notably lower levels of IL-10, Arg-1, and TGFbeta in response to IL-4 treatment	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99685	-	-
Mus musculus	O35678	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colonic cancer cell	expression of macrophage MGLL is decreased in cancer tissues	Mus musculus	-
colonic cancer cell	expression of macrophage MGLL is decreased in cancer tissues and positively correlated with the survival of cancer patients	Homo sapiens	-
macrophage	-	Homo sapiens	-
macrophage	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
MGLL	-	Homo sapiens
MGLL	-	Mus musculus
monoacylglycerol lipase	-	Homo sapiens
monoacylglycerol lipase	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	deficiency of monoacylglycerol lipase (MGLL) results in lipid overload in tumor-associated macrophages. MGLL deficiency promotes CB2/TLR4-dependent macrophage activation, which further suppresses the function of tumor-associated CD8+ T cells, and contributes to lipid accumulation. Treatment with CB2 antagonists delays tumor progression in inoculated and genetic cancer models	Homo sapiens
malfunction	deficiency of monoacylglycerol lipase (MGLL) results in lipid overload in tumor-associated macrophages. MGLL deficiency promotes CB2/TLR4-dependent macrophage activation, which further suppresses the function of tumor-associated CD8+ T cells, and contributes to lipid accumulation. Treatment with CB2 antagonists delays tumor progression in inoculated and genetic cancer models	Mus musculus
physiological function	monoacylglycerol lipase (MGLL) regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression. Analysis of mechanism underlying MGLL-CB2-regulated macrophage activation using in vitro and mouse models with pharmacological or genetic manipulation. MGLL/CB2 regulates tumor progression in mice, macrophage MGLL inhibits tumor progression via CD8+ T cells, mechanism, overview. MGLL regulates macrophage activity via CB2/TLR4 interaction, CB2 antagonizes TLR-4 signaling in macrophages	Mus musculus
physiological function	monoacylglycerol lipase (MGLL) regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression. Analysis of mechanism underlying MGLL-CB2-regulated macrophage activation using in vitro and mouse models with pharmacological or genetic manipulation. Modulation of MGLL-CB2 axis in macrophages might be a promising strategy for cancer treatment. Macrophage MGLL inhibits tumor progression via CD8+ T cells, mechanism, overview. MGLL regulates macrophage activity via CB2/TLR4 interaction	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)