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Literature summary for 3.1.1.23 extracted from

  • Kishimoto, Y.; Cagniard, B.; Yamazaki, M.; Nakayama, J.; Sakimura, K.; Kirino, Y.; Kano, M.
    Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol (2015), Front. Behav. Neurosci., 9, 134 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-arachidonoylglycerol + H2O Mus musculus
-
 arachidonoate + glycerol
-
 ?
2-arachidonoylglycerol + H2O Mus musculus C57BL/6N
-
 arachidonoate + glycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O35678
-
-
Mus musculus C57BL/6N O35678
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
-
 Mus musculus
-
embryonic stem cell
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-arachidonoylglycerol + H2O
-
 Mus musculus arachidonoate + glycerol
-
 ?
2-arachidonoylglycerol + H2O
-
 Mus musculus C57BL/6N arachidonoate + glycerol
-
 ?

Synonyms

Synonyms Comment Organism
MGL
-
 Mus musculus
MGLL UniProt Mus musculus
monoacylglycerol lipase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction task-specific enhancement of hippocampus-dependent learning occurs in mice deficient in monoacylglycerol lipase. In the object recognition and water-finding tests, MGL KO mice exhibit enhanced memory acquisition. In contrast, in the contextual fear conditioning, MGL KO mice tend to show slower memory extinction. Trace eyeblink conditioning is not altered in MGL KO mice throughout the acquisition and extinction phases. Enhanced visuospatial latent memory in MGL KO mice. Extinction of recognition learning is impaired in MGL KO mice. Behavioral phenotype, detailed overview Mus musculus
physiological function monoacylglycerol lipase is the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol. 2-Arachidonoylglycerol (2-AG) signaling is important for hippocampus-dependent learning and memory, but its contribution is highly task-dependent Mus musculus