Literature summary for 3.1.1.23 extracted from

De Leo, M.; Huallpa, C.G.; Alvarado, B.; Granchi, C.; Poli, G.; De Tommasi, N.; Braca, A.
New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL) (2018), Fitoterapia, 130, 251-258 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	no effect by DTT at 0.1 mM	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(4-(4-chlorobenzoyl)piperidin-1-yl)(4-methoxyphenyl)-methanone	-	Homo sapiens
12-deacetylsplendidin C	poor inhibition	Homo sapiens
2-dehydroxysalvileucanthsin A	poor inhibition	Homo sapiens
eriodictyol	-	Homo sapiens
jewenol A	reversible inhibitor, catalytic site binding structure, overview	Homo sapiens
additional information	diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL), NMR structure analysis, molecular docking into the catalytic site of the enzyme, overview. No effect by DTT at 0.1 mM and by galloflavin	Homo sapiens
oleanolic acid	-	Homo sapiens
pedalitin	-	Homo sapiens
Protocatechualdehyde	-	Homo sapiens
pseudorosmaricin	poor inhibition	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q99685	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-nitrophenyl acetate + H2O	-	Homo sapiens	4-nitrophenol + acetate	-	?

Synonyms

Synonyms	Comment	Organism
MAGL	-	Homo sapiens
monoacylglycerol lipase	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	assay at	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0117	-	pH 7.2, temperature not specified in the publication	Homo sapiens	(4-(4-chlorobenzoyl)piperidin-1-yl)(4-methoxyphenyl)-methanone
0.0468	-	pH 7.2, temperature not specified in the publication	Homo sapiens	jewenol A
0.2	-	above, pH 7.2, temperature not specified in the publication	Homo sapiens	12-deacetylsplendidin C
0.2	-	above, pH 7.2, temperature not specified in the publication	Homo sapiens	2-dehydroxysalvileucanthsin A
0.2	-	above, pH 7.2, temperature not specified in the publication	Homo sapiens	pseudorosmaricin

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Release 2023.1 (January 2023)