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Literature summary for 3.1.1.23 extracted from

  • Cao, Z.; Mulvihill, M.M.; Mukhopadhyay, P.; Xu, H.; Erdelyi, K.; Hao, E.; Holovac, E.; Hasko, G.; Cravatt, B.F.; Nomura, D.K.; Pacher, P.
    Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice (2013), Gastroenterology, 144, 808-817.e15.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.23

Inhibitors

Inhibitors Comment Organism Structure
JZL184 selective inhibitor Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Mus musculus
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-arachidonoylglycerol + H2O
-
 Mus musculus glycerol + arachidonic acid
-
 ?

Synonyms

Synonyms Comment Organism
MAGL
-
 Mus musculus
monoacylglycerol lipase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme inactivation attenuates hepatic ischemia/reperfusion-induced tissue injury, inflammation and oxidative stress Mus musculus
physiological function monoacylglycerol lipase promotes hepatic injury via endocannabinoid and eicosanoid signaling Mus musculus