Literature summary for 3.1.1.23 extracted from

Chanda, P.K.; Gao, Y.; Mark, L.; Btesh, J.; Strassle, B.W.; Lu, P.; Piesla, M.J.; Zhang, M.Y.; Bingham, B.; Uveges, A.; Kowal, D.; Garbe, D.; Kouranova, E.V.; Ring, R.H.; Bates, B.; Pangalos, M.N.; Kennedy, J.D.; Whiteside, G.T.; Samad, T.A.
Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system (2010), Mol. Pharmacol., 78, 996-1003.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-arachidonoylglycerol + H2O	more than 80% of 2-arachidonoylglycerol (0.05 mM) is hydrolyzed after 90 min in the presence of 0.02 mg of MAGL(+/+) brain extracts at room temperature	Mus musculus	glycerol + arachidonic acid	-	?

Synonyms

Synonyms	Comment	Organism
MAGL	-	Mus musculus
monoacylglycerol lipase	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	mice lacking MAGL exhibit dramatically reduced 2-arachidonoylglycerol hydrolase activity and highly elevated 2-arachidonoylglycerol levels in the nervous system leading to desensitization of brain CB1 receptors with a significant reduction of cannabimimetic effects of CB1 agonists. MAGL-deficient mice do not show alterations in neuropathic and inflammatory pain sensitivity	Mus musculus
physiological function	monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system	Mus musculus

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Release 2023.1 (January 2023)