Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.23 extracted from

  • Nomura, D.K.; Long, J.Z.; Niessen, S.; Hoover, H.S.; Ng, S.W.; Cravatt, B.F.
    Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis (2010), Cell, 140, 49-61.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
JZL184 irreversible inhibitor Homo sapiens
N-arachidonoyl dopamine
-
Homo sapiens
troglitazone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
MUM-2B cell
-
Homo sapiens
-
MUM-2C cell
-
Homo sapiens
-
OVCAR-3 cell
-
Homo sapiens
-
SKOV-3 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
MAGL
-
Homo sapiens
monoacylglycerol lipase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens monoacylglycerol lipase is highly expressed in aggressive human cancer cells and primary tumors up

General Information

General Information Comment Organism
malfunction disruption of MAGL expression and activity impairs cancer pathogenicity. impairments in MAGL-dependent tumor growth are rescued by a high-fat diet, indicating that exogenous sources of fatty acids can contribute to malignancy in cancers lacking MAGL activity Homo sapiens
physiological function monoacylglycerol lipase (MAGL) regulates a fatty acid network that promotes cancer pathogenesis. MAGL, through hydrolysis of monoacylglycerols, controls free fatty acid levels in cancer cells Homo sapiens