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Literature summary for 3.1.1.23 extracted from
- Inhibition of monoacylglycerol lipase by troglitazone, N-arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays (2010), Br. J. Pharmacol., 161, 1512-1526.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 15-deoxy-DELTA12,14-prostaglandin J2 | - |
Homo sapiens |  |
| 15-deoxy-DELTA12,14-prostaglandin J2 | - |
Rattus norvegicus | |
| AM404 | - |
Homo sapiens | |
| AM404 | - |
Rattus norvegicus | |
| CAY 10415 | - |
Homo sapiens | |
| CAY 10415 | - |
Rattus norvegicus | |
| CAY 10514 | - |
Homo sapiens | |
| CAY 10514 | - |
Rattus norvegicus | |
| ciglitazone | - |
Homo sapiens | |
| ciglitazone | - |
Rattus norvegicus | |
| CP55,940 | - |
Homo sapiens | |
| CP55,940 | - |
Rattus norvegicus | |
| JZL184 | time-dependent inhibitor | Homo sapiens | |
| JZL184 | time-dependent inhibitor | Rattus norvegicus | |
| N-arachidonoyl dopamine | - |
Homo sapiens | |
| N-arachidonoyl dopamine | - |
Rattus norvegicus | |
| rosiglitazone | - |
Homo sapiens | |
| rosiglitazone | - |
Rattus norvegicus | |
| troglitazone | - |
Homo sapiens | |
| troglitazone | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebellum | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oleoylglycerol + H2O | - |
Rattus norvegicus | oleic acid + glycerol | - |
? | |
| 4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MGL | - |
Homo sapiens |
| MGL | - |
Rattus norvegicus |
| monoacylglycerol lipase | - |
Homo sapiens |
| monoacylglycerol lipase | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00041 | - |
pH and temperature not specified in the publication | Rattus norvegicus | troglitazone | |
| 0.00078 | - |
pH and temperature not specified in the publication | Homo sapiens | N-arachidonoyl dopamine | |
| 0.0011 | - |
pH and temperature not specified in the publication | Homo sapiens | troglitazone | |
| 0.0031 | - |
pH and temperature not specified in the publication | Homo sapiens | AM404 | |
| 0.0049 | - |
pH and temperature not specified in the publication | Homo sapiens | CP55,940 | |
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Release 2023.1 (January 2023)
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