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Literature summary for 3.1.1.23 extracted from

  • Hashimotodani, Y.; Ohno-Shosaku, T.; Kano, M.
    Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus (2007), J. Neurosci., 27, 1211-1219.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.23

Inhibitors

Inhibitors Comment Organism Structure
6-methyl-2-p-tolylamino-benzo[d] [1,3]oxazin-4-one i.e. URB754 Mus musculus
6-methyl-2-p-tolylamino-benzo[d] [1,3]oxazin-4-one i.e. URB754 Rattus norvegicus
arachidonoyl trifluoromethylketone causes a gradual suppression of cannabinoid-sensitive IPSCs in cultured hippocampal neurons, the suppression is reversed by blocking CB1 receptors and is attenuated by inhibiting 2-AG synthesis, overview Mus musculus
arachidonoyl trifluoromethylketone causes a gradual suppression of cannabinoid-sensitive IPSCs in cultured hippocampal neurons, the suppression is reversed by blocking CB1 receptors and is attenuated by inhibiting 2-AG synthesis, overview Rattus norvegicus
arachidonoyltrifluoromethyl ketone i.e. ATFMK, inhibition is reversible by AM281 Mus musculus
arachidonoyltrifluoromethyl ketone i.e. ATFMK, inhibition is reversible by AM281 Rattus norvegicus
meloxicam
-
 Mus musculus
meloxicam
-
 Rattus norvegicus
methyl arachidonyl fluorophosphonate causes a gradual suppression of cannabinoid-sensitive IPSCs in cultured hippocampal neurons, the suppression is reversed by blocking CB1 receptors and is attenuated by inhibiting 2-AG synthesis, overview; i.e. MAFP Mus musculus
methyl arachidonyl fluorophosphonate causes a gradual suppression of cannabinoid-sensitive IPSCs in cultured hippocampal neurons, the suppression is reversed by blocking CB1 receptors and is attenuated by inhibiting 2-AG synthesis, overview; i.e. MAFP Rattus norvegicus
additional information inhibitors of other endocannabinoid hydrolyzing enzymes, fatty acid amide hydrolase and cyclooxygenase-2, have no effect on the 2-AG-induced IPSC suppression Mus musculus
additional information inhibitors of other endocannabinoid hydrolyzing enzymes, fatty acid amide hydrolase and cyclooxygenase-2, have no effect on the 2-AG-induced IPSC suppression Rattus norvegicus
tetrahydrolipstatin
-
 Mus musculus
tetrahydrolipstatin
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
axon presynaptic enzyme Mus musculus 30424
-
axon presynaptic enzyme Rattus norvegicus 30424
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-arachidonoylglycerol + H2O Mus musculus presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus glycerol + arachidonic acid
-
 ?
2-arachidonoylglycerol + H2O Rattus norvegicus presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus glycerol + arachidonic acid
-
 ?
2-arachidonoylglycerol + H2O Mus musculus C57BL/6 presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus glycerol + arachidonic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Mus musculus
-
hippocampus
-
 Rattus norvegicus
-
neuron
-
 Mus musculus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-arachidonoylglycerol + H2O
-
 Mus musculus glycerol + arachidonic acid
-
 ?
2-arachidonoylglycerol + H2O
-
 Rattus norvegicus glycerol + arachidonic acid
-
 ?
2-arachidonoylglycerol + H2O presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus Mus musculus glycerol + arachidonic acid
-
 ?
2-arachidonoylglycerol + H2O presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus Rattus norvegicus glycerol + arachidonic acid
-
 ?
2-arachidonoylglycerol + H2O
-
 Mus musculus C57BL/6 glycerol + arachidonic acid
-
 ?
2-arachidonoylglycerol + H2O presynaptic MGL not only hydrolyzes 2-arachidonoylglycerol released from activated postsynaptic neurons but also contributes to degradation of constitutively produced 2-arachidonoylglycerol and prevention of its accumulation around presynaptic terminals. Thus, the MGL activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus Mus musculus C57BL/6 glycerol + arachidonic acid
-
 ?

Synonyms

Synonyms Comment Organism
monoacylglycerol lipase
-
 Mus musculus
monoacylglycerol lipase
-
 Rattus norvegicus