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Literature summary for 3.1.1.23 extracted from
- ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase (2004), J. Neurosci., 24, 8068-8074.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | slightly activating | Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| arachidonyl trifluoromethylketone | - |
Mus musculus | |
| ATP | slightly inhibiting | Mus musculus | |
| methyl arachidonyl fluorophosphonate | - |
Mus musculus | |
| additional information | no inhibition by PMSF and palmityl trifluoromethyl ketone | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Mus musculus | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | slightly activating | Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
x * 30000, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-arachidonoylglycerol + H2O | Mus musculus | 2-arachidonoylglycerol is an endocannabinoid which prevents the propagation of harmful neuroinflammation and may function as a gliotransmitter | arachidonic acid + glycerol | - |
? | |
| additional information | Mus musculus | inhibition of the enzyme potentiates the activation of 2-arachidonoylglycerol production by ATP | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | primary | Mus musculus | - |
| cell culture | - |
Mus musculus | - |
| neuron | primary | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-arachidonoylglycerol + H2O | - |
Mus musculus | arachidonic acid + glycerol | - |
? | |
| 2-arachidonoylglycerol + H2O | 2-arachidonoylglycerol is an endocannabinoid which prevents the propagation of harmful neuroinflammation and may function as a gliotransmitter | Mus musculus | arachidonic acid + glycerol | - |
? | |
| additional information | inhibition of the enzyme potentiates the activation of 2-arachidonoylglycerol production by ATP | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 30000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MGL | - |
Mus musculus |
| monoacylglycerol lipase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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