Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2,3-dichlorophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(2,4-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(2,4-dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(2,5-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(2,6-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(2-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(2-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(2-iodophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(3,4-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(3,4-dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(3,5-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | mixed-type inhibition. A-12 fits well in the catalytic site and is stabilized by hydrophobic interactions. It completely blocks the catalytic assembly of the enzyme and prevents it to participate in ester hydrolysis mechanism. The favorable binding confor | Homo sapiens | |
2-(3,5-dinitrophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(3-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(3-chlorophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(3-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(3-methoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(3-nitrophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(4-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(4-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(4-iodophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(4-methoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(4-methylphenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-(4-nitrophenyl)-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-phenyl-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[2-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[2-fluoro-4-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[2-fluoro-6-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[3,5-bis(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[3-(chloromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[3-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[3-fluoro-5-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[4-(chloromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[4-(dimethylamino)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[4-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[4-fluoro-2-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[4-fluoro-3-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
2-[5-fluoro-2-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | - |
Homo sapiens | |
3-(4-oxo-4H-naphtho[1,2-b]pyran-2-yl)phenyl acetate | - |
Homo sapiens | |
4-(4-oxo-4H-naphtho[1,2-b]pyran-2-yl)phenyl acetate | - |
Homo sapiens | |
additional information | benzoflavones as cholesterol esterase inhibitors, synthesis, biological evaluation, and molecular protein-ligand docking studies using the active site structure of the human CEase (PDB ID 1F6W), overview. 7,8-benzoflavone derivatives are synthesized and evaluated for their inhibitory potential against cholesterol esterase | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19835 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
BAL | - |
Homo sapiens |
bile-salt activated lipase | - |
Homo sapiens |
CEase | - |
Homo sapiens |
cel | - |
Homo sapiens |
cholesterol esterase | - |
Homo sapiens |
hCEase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000078 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(3,5-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00000143 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(2,4-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00000199 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(2,6-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00000322 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(2-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00000524 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(3-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00000681 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(2,5-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00000699 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(3-chlorophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00001085 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(2,3-dichlorophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00001101 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(2-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00001408 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(3,4-difluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00001612 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(2-iodophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.0000201 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(4-fluorophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00002514 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(3-nitrophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00002609 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(3-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00002851 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(4-bromophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00003004 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(3,5-dinitrophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00003415 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(4-iodophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00003733 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-(4-nitrophenyl)-4H-naphtho[1,2-b]pyran-4-one | |
0.00003889 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-[2-fluoro-6-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | |
0.00003898 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-[2-fluoro-4-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | |
0.00003908 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-[4-fluoro-2-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | |
0.00003923 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-[4-(chloromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | |
0.00004003 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-[3-(chloromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | |
0.00004128 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-[5-fluoro-2-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | |
0.00004299 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-[3-fluoro-5-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one | |
0.00004303 | - |
at pH 7.0 and 25°C | Homo sapiens | 2-[4-fluoro-3-(trifluoromethyl)phenyl]-4H-naphtho[1,2-b]pyran-4-one |