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Literature summary for 3.1.1.13 extracted from

  • Lin, M.C.; Yeh, S.J.; Chen, I.R.; Lin, G.
    Stereoselective inhibition of cholesterol esterase by enantiomers of exo- and endo-2-norbornyl-N-n-butylcarbamates (2011), Protein J., 30, 220-227.
    View publication on PubMed
Search for more literature for 3.1.1.13

Inhibitors

Inhibitors Comment Organism Structure
(R)-endo-2-norbornyl-N-n-butyl-carbamate
-
 Sus scrofa
(R)-exo-2-norbornyl-N-n-butylcarbamate the R-enantiomer is 6.8times more potent than the S-enantiomer Sus scrofa
(S)-endo-2-norbornyl-N-n-butyl-carbamate the S-enantiomer is 4.6times more potent than the R-enantiomer Sus scrofa
(S)-exo-2-norbornyl-N-n-butylcarbamate
-
 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl butyrate + H2O
-
 Sus scrofa 4-nitrophenol + butyrate
-
 ?

Synonyms

Synonyms Comment Organism
bile salt-activated lipase
-
 Sus scrofa
Carboxyl ester lipase
-
 Sus scrofa
CEase
-
 Sus scrofa
cholesterol esterase
-
 Sus scrofa
lysophospholipase
-
 Sus scrofa
non-specific lipase
-
 Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0004
-
 (R)-exo-2-norbornyl-N-n-butylcarbamate in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C Sus scrofa
0.0013
-
 (S)-endo-2-norbornyl-N-n-butyl-carbamate in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C Sus scrofa
0.0025
-
 (S)-exo-2-norbornyl-N-n-butylcarbamate in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C Sus scrofa
0.009
-
 (R)-endo-2-norbornyl-N-n-butyl-carbamate in sodium phosphate buffer (0.1 M, pH 7.0), at 25°C Sus scrofa