Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AS115 | nonspecific inhibitor, the enzyme is about 85% inhibited by 0.01 mM AS115 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
x * 40000, human NCEH1 protein is recognized as duplets with molecular mass of 40000 and 45000 Da, SDS-PAGE | Homo sapiens |
45000 | - |
x * 45000, human NCEH1 protein is recognized as duplets with molecular mass of 40000 and 45000 Da, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6PIU2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
macrophage | NCEH1 is expressed in CD68-positive macrophage foam cells of human atherosclerotic lesions | Homo sapiens | - |
monocyte | - |
Homo sapiens | - |
THP-1 cell | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
white adipose tissue | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl oleate + H2O | - |
Homo sapiens | cholesterol + oleate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 40000, human NCEH1 protein is recognized as duplets with molecular mass of 40000 and 45000 Da, SDS-PAGE | Homo sapiens |
? | x * 45000, human NCEH1 protein is recognized as duplets with molecular mass of 40000 and 45000 Da, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Nceh1 | - |
Homo sapiens |
neutral CE hydrolase | - |
Homo sapiens |
neutral cholesterol ester hydrolase 1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | hormone-sensitive lipase inhibition does not decrease neutral cholesterol ester hydrolase 1 activity | additional information |
Homo sapiens | monocyte-derived macrophages show a robust increase in neutral cholesterol ester hydrolase activity during the differentiation from monocytes up to day 8 (14.9fold). Treatment by macrophage colony-stimulating factor and granulocyte/macrophage colony-stimulating factor increases the amounts of NCEH1 protein 2.4fold and 3.5fold, repsectively | up |
General Information | Comment | Organism |
---|---|---|
physiological function | neutral cholesterol ester hydrolase1 is expressed in human atheromatous lesions, where it plays a critical role in the hydrolysis of cholesterol ester in human macrophage foam cells, thereby contributing to the initial part of reverse cholesterol transport in human atherosclerosis | Homo sapiens |