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Literature summary for 3.1.1.13 extracted from

  • Igarashi, M.; Osuga, J.; Uozaki, H.; Sekiya, M.; Nagashima, S.; Takahashi, M.; Takase, S.; Takanashi, M.; Li, Y.; Ohta, K.; Kumagai, M.; Nishi, M.; Hosokawa, M.; Fledelius, C.; Jacobsen, P.; Yagyu, H.; Fukayama, M.; Nagai, R.; Kadowaki, T.; Ohashi, K.; Ishibashi, S.
    The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages (2010), Circ. Res., 107, 1387-1395.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
AS115 nonspecific inhibitor, the enzyme is about 85% inhibited by 0.01 mM AS115 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
x * 40000, human NCEH1 protein is recognized as duplets with molecular mass of 40000 and 45000 Da, SDS-PAGE Homo sapiens
45000
-
x * 45000, human NCEH1 protein is recognized as duplets with molecular mass of 40000 and 45000 Da, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6PIU2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
macrophage NCEH1 is expressed in CD68-positive macrophage foam cells of human atherosclerotic lesions Homo sapiens
-
monocyte
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-
U-937 cell
-
Homo sapiens
-
white adipose tissue
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesteryl oleate + H2O
-
Homo sapiens cholesterol + oleate
-
?

Subunits

Subunits Comment Organism
? x * 40000, human NCEH1 protein is recognized as duplets with molecular mass of 40000 and 45000 Da, SDS-PAGE Homo sapiens
? x * 45000, human NCEH1 protein is recognized as duplets with molecular mass of 40000 and 45000 Da, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Nceh1
-
Homo sapiens
neutral CE hydrolase
-
Homo sapiens
neutral cholesterol ester hydrolase 1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens hormone-sensitive lipase inhibition does not decrease neutral cholesterol ester hydrolase 1 activity additional information
Homo sapiens monocyte-derived macrophages show a robust increase in neutral cholesterol ester hydrolase activity during the differentiation from monocytes up to day 8 (14.9fold). Treatment by macrophage colony-stimulating factor and granulocyte/macrophage colony-stimulating factor increases the amounts of NCEH1 protein 2.4fold and 3.5fold, repsectively up

General Information

General Information Comment Organism
physiological function neutral cholesterol ester hydrolase1 is expressed in human atheromatous lesions, where it plays a critical role in the hydrolysis of cholesterol ester in human macrophage foam cells, thereby contributing to the initial part of reverse cholesterol transport in human atherosclerosis Homo sapiens