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Literature summary for 3.1.1.13 extracted from
- The identity of the cholesteryl ester hydrolase of bovine corpus luteum (1983), Biochem. Soc. Trans., 11, 703.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cAMP-dependent protein kinase type II | 2fold activation in presence of ATP | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diisopropylfluorophosphate | - |
Bos taurus |  |
| Hg2+ | - |
Bos taurus | |
| NaF | - |
Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | activation in a reaction mixture containing cAMP, protein kinase A and ATP | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 84000 | - |
SDS-PAGE | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl esters + H2O | Bos taurus | important rate-limiting step in steroidogenesis | cholesterol + fatty acid | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | phosphoprotein | Bos taurus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial by chromatography techniques | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| corpus luteum | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.34 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl esters + H2O | important rate-limiting step in steroidogenesis | Bos taurus | cholesterol + fatty acid | - |
? | |
| cholesteryl oleate + H2O | - |
Bos taurus | cholesterol + oleic acid | - |
? | |
| triolein + H2O | - |
Bos taurus | dioleoylglycerol + oleic acid | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 84000, SDS-PAGE | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| MgATP2- | increasing activity with addition of cAMP-dependend protein kinase | Bos taurus | |
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Release 2023.1 (January 2023)
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