Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glycocholate | slightly activation at 40 mM | Homo sapiens | |
sodium cholate | - |
Rattus sp. | |
sodium cholate | activates optimal at 40 mM | Homo sapiens | |
sodium taurocholic acid | - |
Rattus sp. | |
sodium taurocholic acid | slightly activation at 40 mM | Homo sapiens |
General Stability | Organism |
---|---|
highly unstable at 4°C | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
brefeldin A | inhibition to 80%-90% of secreted enzyme into the medium of HepG2 cells | Homo sapiens | |
monensin | inhibition to 50%-60% of secreted enzyme into the medium of HepG2 cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
cholesteryl oleate | in presence of 40 mM sodium cholate | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl esters + H2O | Homo sapiens | mediating cholesterol absorption through the gastrointestinal tract, digestion and absorption of dietary fats | cholesterol + fatty acid | - |
? | |
cholesteryl esters + H2O | Rattus sp. | mediating cholesterol absorption through the gastrointestinal tract, digestion and absorption of dietary fats | cholesterol + fatty acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus sp. | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus sp. | - |
liver | hepatoma cells HepG2 | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.002 | - |
- |
Rattus sp. |
0.002 | - |
activity after 6 h in cell homogenate | Homo sapiens |
0.002 | 0.009 | activities of secreted enzyme from 0 h up to 102 h | Homo sapiens |
Storage Stability | Organism |
---|---|
4°C, 0.02 mM bovine serum albumin, 20 h | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl esters + H2O | mediating cholesterol absorption through the gastrointestinal tract, digestion and absorption of dietary fats | Homo sapiens | cholesterol + fatty acid | - |
? | |
cholesteryl esters + H2O | mediating cholesterol absorption through the gastrointestinal tract, digestion and absorption of dietary fats | Rattus sp. | cholesterol + fatty acid | - |
? | |
cholesteryl oleate + H2O | - |
Homo sapiens | cholesterol + oleic acid | - |
? | |
cholesteryl oleate + H2O | - |
Rattus sp. | cholesterol + oleic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
bile salt-dependent cholesteryl ester hydrolase | - |
Homo sapiens |
bile salt-dependent cholesteryl ester hydrolase | - |
Rattus sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Homo sapiens |