Activating Compound | Comment | Organism | Structure |
---|---|---|---|
17beta-estradiol | enhanced hydrolysis of cholesteryl oleate in time- and dose-dependent manner | Mus musculus | |
cAMP-dependent protein kinase type II | increasing activity on cholesteryl oleate hydrolysis, increasing protein kinase synthesis due to addition of 17beta-estradiol | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
progesterone | 38% inhibition at 0.06 mM | Mus musculus | |
testosterone | 19% inhibition at 0.035 mM | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
cholesteryl oleate | in presence of cofactors | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activation in a reaction mixture containing cAMP, protein kinase A and ATP | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl esters + H2O | Mus musculus | involvement in arteriosclerosis | cholesterol + fatty acid | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | J774 A.1 cells | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl esters + H2O | involvement in arteriosclerosis | Mus musculus | cholesterol + fatty acid | - |
r | |
cholesteryl oleate + H2O | - |
Mus musculus | cholesterol + oleic acid | - |
r |
Synonyms | Comment | Organism |
---|---|---|
N-CEase | - |
Mus musculus |
neutral cholesterol esterase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cAMP | as cofactor for cAMP-dependent protein kinase | Mus musculus | |
MgATP2- | - |
Mus musculus |