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Literature summary for 3.1.1.13 extracted from
- Molecular recognition by cholesterol esterase of active site ligands: structure-reactivity effects for inhibition by aryl carbamates and subsequent carbamylenzyme turnover (1996), Biochemistry, 35, 16723-16734.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| sodium taurocholic acid | modulate lack of bile salt effect on fatty acid recognition | Rattus sp. |  |
| sodium taurocholic acid | modulates both the steroid and fatty acid binding sites | Sus scrofa | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-naphthyl-N-butyl carbamate | biphasic time course, reversible non-covalent enzyme-carbamate complex | Rattus sp. | |
| aryl-N-alkyl carbamates | - |
Rattus sp. | |
| aryl-N-alkyl carbamates | - |
Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl esters + H2O | Sus scrofa | fatty acid binding site more hydrophobic than steroid binding site | cholesterol + fatty acid | - |
r | |
| cholesteryl esters + H2O | Rattus sp. | fatty acid binding site more hydrophobic than steroid binding site | cholesterol + fatty acid | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus sp. | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Sus scrofa | - |
| pancreas | - |
Rattus sp. | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl esters + H2O | fatty acid binding site more hydrophobic than steroid binding site | Sus scrofa | cholesterol + fatty acid | - |
r | |
| cholesteryl esters + H2O | fatty acid binding site more hydrophobic than steroid binding site | Rattus sp. | cholesterol + fatty acid | - |
r | |
| p-nitrophenyl butyrate + H2O | - |
Sus scrofa | p-nitrophenol + butanoic acid | - |
? | |
| p-nitrophenyl butyrate + H2O | - |
Rattus sp. | p-nitrophenol + butanoic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CEase | - |
Sus scrofa |
| CEase | - |
Rattus sp. |
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