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Literature summary for 3.1.1.118 extracted from
- The main triglyceride-lipase from the insect fat body is an active phospholipase A(1) identification and characterization (2006), J. Lipid Res., 47, 2656-2667 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| methyl arachidonyl flurophosphonate | potent inhibitor | Manduca sexta | |
| additional information | not inhibited by 7,7-dimethyleicosadienoic acid and bromoenol-lactone | Manduca sexta |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Manduca sexta | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Manduca sexta | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the enzyme is phosphorylated in vitro by protein kinase A | Manduca sexta |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| DEAE Sepharose column chromatography, Q Sepharose column chromatography, hydroxyapatite column chromatography, and phenyl Sepharose column chromatography | Manduca sexta |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fat body | - |
Manduca sexta | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine + H2O | - |
Manduca sexta | 2-oleoyl-sn-glycerol-3-phosphocholine + palmitate | - |
? |  |
| 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamine + H2O | - |
Manduca sexta | 2-oleoyl-sn-glycerol-3-phosphoethanolamine + palmitate | - |
? | |
| triolein + H2O | - |
Manduca sexta | diolein + oleate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 76000, SDS-PAGE | Manduca sexta |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PA-PLA1 | - |
Manduca sexta |
| phosphatidic acid-preferring phospholipase A1 | - |
Manduca sexta |
| TG-lipase | - |
Manduca sexta |
| triglyceride-lipase | - |
Manduca sexta |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Manduca sexta | isoelectric focusing | - |
5.86 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the phospholipase activity of the enzyme is required to allow access of the lipase to triglyceride molecules contained in the core of the lipid droplets | Manduca sexta |
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