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Literature summary for 3.1.1.118 extracted from

  • Yadav, P.K.; Rajasekharan, R.
    Misregulation of a DDHD domain-containing lipase causes mitochondrial dysfunction in yeast (2016), J. Biol. Chem., 291, 18562-18581 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.118

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
G499A the mutant shows reduced activity compared to the wild type enzyme Saccharomyces cerevisiae
G503A the mutant shows reduced activity compared to the wild type enzyme Saccharomyces cerevisiae
S501A inactive Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dioleoyl-sn-glycero-3-phospho-(1-rac-glycerol) + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) + oleate
-
 ?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phosphoethanolamine + oleate
-
 ?
1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1-racglycerol) + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) + palmitate
-
 ?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phosphoethanolamine + palmitate
-
 ?
1-stearoyl-2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) + stearate
-
 ?
1-stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phosphoethanolamine + stearate
-
 ?
cardiolipin + H2O
-
 Saccharomyces cerevisiae ?
-
 ?

Subunits

Subunits Comment Organism
? x * 80000, SDS-PAGE Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
DDHD domaincontaining lipase 1
-
 Saccharomyces cerevisiae
DDL1
-
 Saccharomyces cerevisiae
PA-PLA1
-
 Saccharomyces cerevisiae
Yor022c
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction the misregulation of the enzyme gene by Aft1/2 transcription factors alters cardiolipin metabolism and causes mitochondrial dysfunction in the cells Saccharomyces cerevisiae