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Literature summary for 3.1.1.118 extracted from

  • Baba, T.; Kashiwagi, Y.; Arimitsu, N.; Kogure, T.; Edo, A.; Maruyama, T.; Nakao, K.; Nakanishi, H.; Kinoshita, M.; Frohman, M.A.; Yamamoto, A.; Tani, K.
    Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics (2014), J. Biol. Chem., 289, 11497-11511 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Mus musculus

Protein Variants

Protein Variants Comment Organism
S537A the mutant shows reduced activity compared to the wild type enzyme Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q80YA3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain high expression Mus musculus
-
liver weak expression Mus musculus
-
lung
-
Mus musculus
-
additional information not expressed in spermatocytes or spermatogonia Mus musculus
-
spermatid
-
Mus musculus
-
testis highest expression Mus musculus
-
thymus
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
DDHD1
-
Mus musculus
KIAA0725p
-
Mus musculus
PA-PLA1
-
Mus musculus
phosphatidic acid-preferring phospholipase A1
-
Mus musculus

General Information

General Information Comment Organism
malfunction enzyme gene disruption in mice causes sperm malformation due to mitochondrial organization defects Mus musculus
physiological function the enzyme regulates mitochondrial dynamics and is involved in the organization of mitochondria during spermiogenesis Mus musculus