Literature summary for 3.1.1.116 extracted from

Ishiguro, H.; Higuchi, S.; Arinami, T.; Onaivi, E.S.
Association between alcoholism and the gene encoding the endocannabinoid synthesizing enzyme diacylglycerol lipase alpha in the Japanese population (2018), Alcohol, 68, 59-62 .

Search for more literature for 3.1.1.116

Cloned(Commentary)

Cloned (Comment)	Organism
gene DAGLA	Mus musculus
gene DAGLA, located on the human chromosome 11q12.2	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	genotyping, three SNPs in the DAGLA gene, rs879486(C_8906779_10), rs9735635(C_25958391_10) and rs3741252/Pro899Leu(C_25959741_10), are used for screening as tag SNPs across the gene. One of those SNPs, rs879486, is excluded from the final analysis in all the subjects, since rs879486 does not show association with alcoholism in the Japanese subjects. But associations are observed for the other two polymorphisms, rs9735635 and rs3741252/Pro899Leu, in the screening. Significant differences are found between those two polymorphisms and alcoholism in the Japanese population studied	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1-acyl-2-arachidonoyl-sn-glycerol + H2O	Homo sapiens	-	2-arachidonoylglycerol + fatty acid	-	?
1-acyl-2-arachidonoyl-sn-glycerol + H2O	Mus musculus	-	2-arachidonoylglycerol + fatty acid	-	?
1-acyl-2-arachidonoyl-sn-glycerol + H2O	Mus musculus C57BL/6JJmsSLC	-	2-arachidonoylglycerol + fatty acid	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y4D2	-	-
Mus musculus	Q6WQJ1	-	-
Mus musculus C57BL/6JJmsSLC	Q6WQJ1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
brain	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-acyl-2-arachidonoyl-sn-glycerol + H2O	-	Homo sapiens	2-arachidonoylglycerol + fatty acid	-	?
1-acyl-2-arachidonoyl-sn-glycerol + H2O	-	Mus musculus	2-arachidonoylglycerol + fatty acid	-	?
1-acyl-2-arachidonoyl-sn-glycerol + H2O	-	Mus musculus C57BL/6JJmsSLC	2-arachidonoylglycerol + fatty acid	-	?

Synonyms

Synonyms	Comment	Organism
DAGLA	-	Homo sapiens
DAGLA	-	Mus musculus
diacylglycerol lipase alpha	-	Homo sapiens
diacylglycerol lipase alpha	-	Mus musculus
endocannabinoid synthesizing enzyme	-	Homo sapiens
endocannabinoid synthesizing enzyme	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	possible association between alcoholism and single nucleotide polymorphisms (SNPs) of the human DAGLA gene in Japanese population	Homo sapiens
physiological function	the endocannabinoid system is involved in neuropsychiatric diseases, in addiction and other mental disorders including depression, posttraumatic stress disorder and schizophrenia. The endocannabinoid system regulates as a filter of input signal to dopaminergic neuron with dramatic changes in the reward-relevant brain, such as in the midbrain and in the stratum during alcohol intake, alcohol deprivation, and relapse. 2-Arachidonoyl glycerol (2-AG) is one of the two main endocannabinoids, and their regulation can play roles in the disorders under the environmental influence. Involvement of diacylglycerol lipase alpha (DAGLA), that is a 2-AG biosynthesizing enzyme in the pathogenesis of alcoholism, and possible association between alcoholism and single nucleotide polymorphisms (SNPs) of the human DAGLA gene in Japanese population. The involvement of DAGLA in alcoholism is possible by its genetic dysfunction and also by influence of stress. Analysis of interaction of DAGLA gene and stress, overview	Homo sapiens
physiological function	the endocannabinoid system is involved in neuropsychiatric diseases, in addiction and other mental disorders including depression, posttraumatic stress disorder and schizophrenia. The endocannabinoid system regulates as a filter of input signal to dopaminergic neuron with dramatic changes in the reward-relevant brain, such as in the midbrain and in the stratum during alcohol intake, alcohol deprivation, and relapse. Analysis of interaction of DAGLA gene and stress, overview. Considerable correlation is observed between alcohol preference and the Dagla expression. More preference to alcohol seems to induce more reduction of the Dagla expression in the brain of mice, while the mice intraperitoneally injected with 4% alcohol for 7 days show no difference from the mice injected with saline indicating that the difference of Dagla gene is not due to the amount of ethanol consumption in mice	Mus musculus

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Release 2023.1 (January 2023)