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Literature summary for 3.1.1.106 extracted from

  • Haikarainen, T.; Lehtioe, L.
    Proximal ADP-ribose hydrolysis in Trypanosomatids is catalyzed by a macrodomain (2016), Sci. Rep., 6, 24213 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.106

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Trypanosoma cruzi
expressed in Escherichia coli BL21(DE3) cells Trypanosoma brucei gambiense

Crystallization (Commentary)

Crystallization (Comment) Organism
apoenzyme and in complex with ADP-D-ribose or ADP, sitting drop vapor diffusion method, using 20-25% (w/v) PEG 3350 Trypanosoma brucei gambiense
apoenzyme, sitting drop vapor diffusion method, using 0.1 M Bis-Tris propane pH 8.0, 0.96 M trisodium citrate Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2''-O-acetyl-ADP-D-ribose + H2O Trypanosoma cruzi
-
 ADP-D-ribose + acetate
-
 ?
2''-O-acetyl-ADP-D-ribose + H2O Trypanosoma brucei gambiense
-
 ADP-D-ribose + acetate
-
 ?
2''-O-acetyl-ADP-D-ribose + H2O Trypanosoma cruzi CL Brener
-
 ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O Trypanosoma cruzi
-
 ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O Trypanosoma brucei gambiense
-
 ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O Trypanosoma cruzi CL Brener
-
 ADP-D-ribose + acetate
-
 ?
[protein]-ADP-D-ribose + H2O Trypanosoma cruzi
-
 [protein] + ADP-D-ribose
-
 ?
[protein]-ADP-D-ribose + H2O Trypanosoma brucei gambiense
-
 [protein] + ADP-D-ribose
-
 ?
[protein]-ADP-D-ribose + H2O Trypanosoma cruzi CL Brener
-
 [protein] + ADP-D-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei gambiense C9ZP98
-
-
Trypanosoma cruzi Q4DQ03
-
-
Trypanosoma cruzi CL Brener Q4DQ03
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography and Superdex 75 gel filtration Trypanosoma cruzi
HisTrap column chromatography and Superdex 75 gel filtration Trypanosoma brucei gambiense

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma cruzi ADP-D-ribose + acetate
-
 ?
2''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma brucei gambiense ADP-D-ribose + acetate
-
 ?
2''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma cruzi CL Brener ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma cruzi ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma brucei gambiense ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O
-
 Trypanosoma cruzi CL Brener ADP-D-ribose + acetate
-
 ?
[protein]-ADP-D-ribose + H2O
-
 Trypanosoma cruzi [protein] + ADP-D-ribose
-
 ?
[protein]-ADP-D-ribose + H2O
-
 Trypanosoma brucei gambiense [protein] + ADP-D-ribose
-
 ?
[protein]-ADP-D-ribose + H2O
-
 Trypanosoma cruzi CL Brener [protein] + ADP-D-ribose
-
 ?

Synonyms

Synonyms Comment Organism
ADP-ribose hydrolase
-
 Trypanosoma cruzi
ADP-ribose hydrolase
-
 Trypanosoma brucei gambiense
MacroD-like protein
-
 Trypanosoma cruzi
MacroD-like protein
-
 Trypanosoma brucei gambiense
MDO
-
 Trypanosoma cruzi
MDO
-
 Trypanosoma brucei gambiense