Proximal ADP-ribose hydrolysis in Trypanosomatids is catalyzed by a macrodomain

Haikarainen, T.; Lehtioe, L.; Sci. Rep. 6, 24213 (2016)

Data extracted from this reference:

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

2''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma cruzi

-

ADP-D-ribose + acetate

-

-

?

2''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma brucei gambiense

-

ADP-D-ribose + acetate

-

-

?

2''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma cruzi CL Brener

-

ADP-D-ribose + acetate

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma cruzi

-

ADP-D-ribose + acetate

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma brucei gambiense

-

ADP-D-ribose + acetate

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma cruzi CL Brener

-

ADP-D-ribose + acetate

-

-

?

[protein]-ADP-D-ribose + H2O

Trypanosoma cruzi

-

[protein] + ADP-D-ribose

-

-

?

[protein]-ADP-D-ribose + H2O

Trypanosoma brucei gambiense

-

[protein] + ADP-D-ribose

-

-

?

[protein]-ADP-D-ribose + H2O

Trypanosoma cruzi CL Brener

-

[protein] + ADP-D-ribose

-

-

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

2''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi

ADP-D-ribose + acetate

-

-

-

?

2''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma brucei gambiense

ADP-D-ribose + acetate

-

-

-

?

2''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi CL Brener

ADP-D-ribose + acetate

-

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi

ADP-D-ribose + acetate

-

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma brucei gambiense

ADP-D-ribose + acetate

-

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi CL Brener

ADP-D-ribose + acetate

-

-

-

?

[protein]-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi

[protein] + ADP-D-ribose

-

-

-

?

[protein]-ADP-D-ribose + H2O

-

752189

Trypanosoma brucei gambiense

[protein] + ADP-D-ribose

-

-

-

?

[protein]-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi CL Brener

[protein] + ADP-D-ribose

-

-

-

?

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

2''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma cruzi

-

ADP-D-ribose + acetate

-

-

?

2''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma brucei gambiense

-

ADP-D-ribose + acetate

-

-

?

2''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma cruzi CL Brener

-

ADP-D-ribose + acetate

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma cruzi

-

ADP-D-ribose + acetate

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma brucei gambiense

-

ADP-D-ribose + acetate

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

Trypanosoma cruzi CL Brener

-

ADP-D-ribose + acetate

-

-

?

[protein]-ADP-D-ribose + H2O

Trypanosoma cruzi

-

[protein] + ADP-D-ribose

-

-

?

[protein]-ADP-D-ribose + H2O

Trypanosoma brucei gambiense

-

[protein] + ADP-D-ribose

-

-

?

[protein]-ADP-D-ribose + H2O

Trypanosoma cruzi CL Brener

-

[protein] + ADP-D-ribose

-

-

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

2''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi

ADP-D-ribose + acetate

-

-

-

?

2''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma brucei gambiense

ADP-D-ribose + acetate

-

-

-

?

2''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi CL Brener

ADP-D-ribose + acetate

-

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi

ADP-D-ribose + acetate

-

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma brucei gambiense

ADP-D-ribose + acetate

-

-

-

?

3''-O-acetyl-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi CL Brener

ADP-D-ribose + acetate

-

-

-

?

[protein]-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi

[protein] + ADP-D-ribose

-

-

-

?

[protein]-ADP-D-ribose + H2O

-

752189

Trypanosoma brucei gambiense

[protein] + ADP-D-ribose

-

-

-

?

[protein]-ADP-D-ribose + H2O

-

752189

Trypanosoma cruzi CL Brener

[protein] + ADP-D-ribose

-

-

-

?

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

750645

Agnew

MacroD1 is a promiscuous ADP- ...

Homo sapiens, Mus musculus

Front. Microbiol.

9

20

2018

-

-

-

-

-

-

-

-

2

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-

8

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-

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-

-

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-

-

-

-

-

-

-

-

-

-

-

-

-

-

2

-

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-

-

-

-

5

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8

2

-

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752262

Haikarainen

Development of an inhibitor s ...

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SLAS Discov.

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255-263

2018

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752189

Haikarainen

Proximal ADP-ribose hydrolysi ...

Trypanosoma brucei gambiense, Trypanosoma cruzi, Trypanosoma cruzi CL Brener

Sci. Rep.

6

24213

2016

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-

6

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2

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2

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-

-

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9

-

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2

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9

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1

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3

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1

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2

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2

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2

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2

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2

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2

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1

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1

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1

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1

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3

4

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1

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1

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1

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6

1

-

-

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1

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3

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2

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-

2

-

1

-

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-

-

-

-

-

2

1

3

-

-

-

-

-

-

-

-

1

-

-

1

-

-

-

-

3

-

-

2

1

-

-

1

-

2

-

-

-

-

-

-

-

-

2

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

751012

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Analysis of O-acetyl-ADP-ribo ...

Homo sapiens, Saccharomyces cerevisiae

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277

47114-47122

2002

-

-

-

-

-

-

-

-

2

-

-

4

-

2

-

-

-

-

-

3

-

-

4

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

2

-

-

4

-

-

-

-

-

3

-

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4

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-