Data extracted from this reference:
Cloned(Commentary)
expressed in Escherichia coli BL21(DE3) cells
Trypanosoma brucei gambiense
expressed in Escherichia coli BL21(DE3) cells
Trypanosoma cruzi
Crystallization (Commentary)
apoenzyme and in complex with ADP-D-ribose or ADP, sitting drop vapor diffusion method, using 20-25% (w/v) PEG 3350
Trypanosoma brucei gambiense
apoenzyme, sitting drop vapor diffusion method, using 0.1 M Bis-Tris propane pH 8.0, 0.96 M trisodium citrate
Trypanosoma cruzi
Natural Substrates/ Products (Substrates)
2''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma cruzi
ADP-D-ribose + acetate
?
2''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma brucei gambiense
ADP-D-ribose + acetate
?
2''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma cruzi CL Brener
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma cruzi
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma brucei gambiense
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma cruzi CL Brener
ADP-D-ribose + acetate
?
[protein]-ADP-D-ribose + H2O
Trypanosoma cruzi
[protein] + ADP-D-ribose
?
[protein]-ADP-D-ribose + H2O
Trypanosoma brucei gambiense
[protein] + ADP-D-ribose
?
[protein]-ADP-D-ribose + H2O
Trypanosoma cruzi CL Brener
[protein] + ADP-D-ribose
?
Organism
Trypanosoma brucei gambiense
C9ZP98
Trypanosoma cruzi CL Brener
Q4DQ03
Purification (Commentary)
HisTrap column chromatography and Superdex 75 gel filtration
Trypanosoma brucei gambiense
HisTrap column chromatography and Superdex 75 gel filtration
Trypanosoma cruzi
Substrates and Products (Substrate)
2''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma cruzi
ADP-D-ribose + acetate
?
2''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma brucei gambiense
ADP-D-ribose + acetate
?
2''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma cruzi CL Brener
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma cruzi
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma brucei gambiense
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma cruzi CL Brener
ADP-D-ribose + acetate
?
[protein]-ADP-D-ribose + H2O
752189
Trypanosoma cruzi
[protein] + ADP-D-ribose
?
[protein]-ADP-D-ribose + H2O
752189
Trypanosoma brucei gambiense
[protein] + ADP-D-ribose
?
[protein]-ADP-D-ribose + H2O
752189
Trypanosoma cruzi CL Brener
[protein] + ADP-D-ribose
?
Synonyms
ADP-ribose hydrolase
Trypanosoma brucei gambiense
ADP-ribose hydrolase
Trypanosoma cruzi
MacroD-like protein
Trypanosoma brucei gambiense
MacroD-like protein
Trypanosoma cruzi
MDO
Trypanosoma brucei gambiense
Cloned(Commentary) (protein specific)
expressed in Escherichia coli BL21(DE3) cells
Trypanosoma brucei gambiense
expressed in Escherichia coli BL21(DE3) cells
Trypanosoma cruzi
Crystallization (Commentary) (protein specific)
apoenzyme and in complex with ADP-D-ribose or ADP, sitting drop vapor diffusion method, using 20-25% (w/v) PEG 3350
Trypanosoma brucei gambiense
apoenzyme, sitting drop vapor diffusion method, using 0.1 M Bis-Tris propane pH 8.0, 0.96 M trisodium citrate
Trypanosoma cruzi
Natural Substrates/ Products (Substrates) (protein specific)
2''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma cruzi
ADP-D-ribose + acetate
?
2''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma brucei gambiense
ADP-D-ribose + acetate
?
2''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma cruzi CL Brener
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma cruzi
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma brucei gambiense
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
Trypanosoma cruzi CL Brener
ADP-D-ribose + acetate
?
[protein]-ADP-D-ribose + H2O
Trypanosoma cruzi
[protein] + ADP-D-ribose
?
[protein]-ADP-D-ribose + H2O
Trypanosoma brucei gambiense
[protein] + ADP-D-ribose
?
[protein]-ADP-D-ribose + H2O
Trypanosoma cruzi CL Brener
[protein] + ADP-D-ribose
?
Purification (Commentary) (protein specific)
HisTrap column chromatography and Superdex 75 gel filtration
Trypanosoma brucei gambiense
HisTrap column chromatography and Superdex 75 gel filtration
Trypanosoma cruzi
Substrates and Products (Substrate) (protein specific)
2''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma cruzi
ADP-D-ribose + acetate
?
2''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma brucei gambiense
ADP-D-ribose + acetate
?
2''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma cruzi CL Brener
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma cruzi
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma brucei gambiense
ADP-D-ribose + acetate
?
3''-O-acetyl-ADP-D-ribose + H2O
752189
Trypanosoma cruzi CL Brener
ADP-D-ribose + acetate
?
[protein]-ADP-D-ribose + H2O
752189
Trypanosoma cruzi
[protein] + ADP-D-ribose
?
[protein]-ADP-D-ribose + H2O
752189
Trypanosoma brucei gambiense
[protein] + ADP-D-ribose
?
[protein]-ADP-D-ribose + H2O
752189
Trypanosoma cruzi CL Brener
[protein] + ADP-D-ribose
?
Other publictions for EC 3.1.1.106
750645
Agnew
MacroD1 is a promiscuous ADP- ...
Homo sapiens, Mus musculus
Front. Microbiol.
9
20
2018
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752262
Haikarainen
Development of an inhibitor s ...
Homo sapiens
SLAS Discov.
23
255-263
2018
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1
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5
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752189
Haikarainen
Proximal ADP-ribose hydrolysi ...
Trypanosoma brucei gambiense, Trypanosoma cruzi, Trypanosoma cruzi CL Brener
Sci. Rep.
6
24213
2016
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2
2
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9
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8
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9
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9
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751419
Zhang
Structural insights into the ...
Escherichia coli
J. Struct. Biol.
192
478-486
2015
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1
1
4
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3
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1
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1
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4
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1
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3
3
749471
Hirsch
Transition-state analysis of ...
Homo sapiens
ACS Chem. Biol.
9
2255-2262
2014
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1
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2
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2
2
751688
Rosenthal
Macrodomain-containing protei ...
Homo sapiens
Nat. Struct. Mol. Biol.
20
502-507
2013
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1
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1
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6
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5
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1
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13
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6
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3
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1
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6
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13
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1
3
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751029
Chen
Identification of macrodomain ...
Escherichia coli, Homo sapiens, Staphylococcus aureus
J. Biol. Chem.
286
13261-13271
2011
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1
1
15
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3
4
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8
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8
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1
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1
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12
-
13
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18
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1
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1
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1
15
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4
1
4
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8
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1
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2
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12
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18
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4
4
751030
Kasamatsu
Hydrolysis of O-acetyl-ADP-ri ...
Homo sapiens
J. Biol. Chem.
286
21110-21117
2011
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4
1
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1
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1
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1
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6
1
3
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1
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3
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3
4
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1
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6
1
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1
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752026
Ono
The 39-kDa poly(ADP-ribose) g ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
103
16687-16691
2006
1
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3
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2
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1
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1
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2
1
3
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1
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1
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1
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2
1
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751012
Rafty
-
Analysis of O-acetyl-ADP-ribo ...
Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
277
47114-47122
2002
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