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Literature summary for 3.1.1.103 extracted from

  • Rahman, M.; Hunter, H.; Prova, S.; Verma, V.; Qamar, A.; Golemi-Kotra, D.
    The Staphylococcus aureus methicillin resistance factor FmtA is a D-amino esterase that acts on teichoic acids (2016), mBio, 7, e0207015 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.103

Protein Variants

Protein Variants Comment Organism
K130A the mutant has 16% of wild type activity Staphylococcus aureus
S127A the mutant has 16% of wild type activity Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell wall
-
 Staphylococcus aureus 5618
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Staphylococcus aureus the enzyme hydrolyzes the ester bond between D-Ala and the backbone of teichoic acids, which are polyglycerol-phosphate or polyribitol-phosphate polymers found in the Staphylococcus aureus cell envelope ?
-
 ?
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O Staphylococcus aureus
-
 [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme hydrolyzes the ester bond between D-Ala and the backbone of teichoic acids, which are polyglycerol-phosphate or polyribitol-phosphate polymers found in the Staphylococcus aureus cell envelope Staphylococcus aureus ?
-
 ?
additional information the enzyme shows very low esterase activity on 4-nitrophenyl butyrate and 4-nitrophenyl acetate, and no activity with D-alanine methyl ester and L-alanine 4-nitroanilide Staphylococcus aureus ?
-
 ?
Nalpha,Nepsilon-diacetyl-Lys-D-Ala-D-Ala + H2O
-
 Staphylococcus aureus Nalpha,Nepsilon-diacetyl-Lys-D-Ala + D-alanine
-
 ?
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + H2O
-
 Staphylococcus aureus [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-ManNAc-GlcNAc-PP-peptidoglycan + D-alanine
-
 ?

Synonyms

Synonyms Comment Organism
fmtA
-
 Staphylococcus aureus

General Information

General Information Comment Organism
physiological function the enzyme modulates D-alanylation of teichoic acids and is involved in cell division, biofilm formation, autolysis, and colonization Staphylococcus aureus