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Literature summary for 3.1.1.1 extracted from
- Diterpenoids from the roots of Euphorbia ebracteolata and their inhibitory effects on human carboxylesterase 2 (2018), Phytochemistry, 146, 82-90 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-D-(6'-galloyl)-glucopyranoside | - |
Homo sapiens |  |
| 13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-Dglucopyranoside | - |
Homo sapiens | |
| 4beta,9alpha,16,20-tetrahydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione | competitive inhibition | Homo sapiens | |
| 4beta,9alpha,20-trihydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione | - |
Homo sapiens | |
| bisdehydrophorbol | - |
Homo sapiens | |
| didehydrolangduin A-20-O-beta-D-glucopyranoside | - |
Homo sapiens | |
| ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside | - |
Homo sapiens | |
| ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-glucopyranoside | - |
Homo sapiens | |
| ent-kaurane-16beta,17-diol-3,12-dione-19-O-beta-D-glucopyranoside | - |
Homo sapiens | |
| ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside | - |
Homo sapiens | |
| ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-glucopyranoside | - |
Homo sapiens | |
| fischeroside A | - |
Homo sapiens | |
| fischeroside A-16-O-beta-D-glucopyranoside | - |
Homo sapiens | |
| ingenol-19-O-beta-D-glucopyranoside | - |
Homo sapiens | |
| langduin F | - |
Homo sapiens | |
| additional information | diterpenoids and glycosides are isolated from roots of Euphorbia ebracteolata and their inhibitory potency and structure is determined, NMR spectrometric analysis, overview | Homo sapiens | |
| phorbol-13-acetate | - |
Homo sapiens | |
| yuexiandajisu D | - |
Homo sapiens | |
| yuexiandajisu E | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O00748 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carboxylesterase 2 | - |
Homo sapiens |
| hCE-2 | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00494 | - |
4beta,9alpha,16,20-tetrahydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione | pH and temperature not specified in the publication | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00388 | - |
pH and temperature not specified in the publication | Homo sapiens | 4beta,9alpha,16,20-tetrahydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione | |
| 0.00395 | - |
pH and temperature not specified in the publication | Homo sapiens | 4beta,9alpha,20-trihydroxy-14(13->12)-abeo-12alphaH-1,6-tigliadiene-3,13-dione | |
| 0.00447 | - |
pH and temperature not specified in the publication | Homo sapiens | yuexiandajisu E | |
| 0.00479 | - |
pH and temperature not specified in the publication | Homo sapiens | yuexiandajisu D | |
| 0.00499 | - |
pH and temperature not specified in the publication | Homo sapiens | bisdehydrophorbol | |
| 0.00521 | - |
pH and temperature not specified in the publication | Homo sapiens | langduin F | |
| 0.00883 | - |
pH and temperature not specified in the publication | Homo sapiens | phorbol-13-acetate | |
| 0.01346 | - |
pH and temperature not specified in the publication | Homo sapiens | didehydrolangduin A-20-O-beta-D-glucopyranoside | |
| 0.01786 | - |
pH and temperature not specified in the publication | Homo sapiens | ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside | |
| 0.02168 | - |
pH and temperature not specified in the publication | Homo sapiens | fischeroside A | |
| 0.0293 | - |
pH and temperature not specified in the publication | Homo sapiens | fischeroside A-16-O-beta-D-glucopyranoside | |
| 0.03249 | - |
pH and temperature not specified in the publication | Homo sapiens | ingenol-19-O-beta-D-glucopyranoside | |
| 0.05327 | - |
pH and temperature not specified in the publication | Homo sapiens | ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-(6'-galloyl)-glucopyranoside | |
| 0.1 | - |
pH and temperature not specified in the publication | Homo sapiens | 13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-D-(6'-galloyl)-glucopyranoside | |
| 0.1 | - |
pH and temperature not specified in the publication | Homo sapiens | 13beta,19-dihydroy-3,15-dioxoatis-16-ene-19-O-beta-Dglucopyranoside | |
| 0.1 | - |
pH and temperature not specified in the publication | Homo sapiens | ent-16beta,17-dihydroxyatisan-3-one-19-O-beta-D-glucopyranoside | |
| 0.1 | - |
pH and temperature not specified in the publication | Homo sapiens | ent-kaurane-16beta,17-diol-3,12-dione-19-O-beta-D-glucopyranoside | |
| 0.1 | - |
pH and temperature not specified in the publication | Homo sapiens | ent-kaurane-16beta,17-diol-3-one-19-O-beta-D-glucopyranoside | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | the enzyme belongs to the serine protease superfamily | Homo sapiens |
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