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Literature summary for 3.1.1.1 extracted from

  • Miwa, S.; Treumann, A.; Bell, A.; Vistoli, G.; Nelson, G.; Hay, S.; von Zglinicki, T.
    Carboxylesterase converts Amplex red to resorufin implications for mitochondrial H2O2 release assays (2016), Free Radic. Biol. Med., 90, 173-183 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.1

Inhibitors

Inhibitors Comment Organism Structure
PMSF PMSF targets the serine residue in the active site of enzyme Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
-
 Mus musculus 5759
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q8VCC2 liver enzyme
-
Mus musculus C57BL/6 Q8VCC2 liver enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
brain very low activity Mus musculus
-
cell culture
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
lung very low activity Mus musculus
-
additional information no activity in heart, skeletal muscle, and testis Mus musculus
-
pancreas very low activity Mus musculus
-
small intestine
-
 Mus musculus
-
spleen very low activity Mus musculus
-
stomach
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Amplex red + H2O Amplex red is readily converted to resorufin by a carboxylesterase without requiring H2O2, horseradish peroxidase, or oxygen Mus musculus resorufin + acetate
-
 ?
Amplex red + H2O Amplex red is readily converted to resorufin by a carboxylesterase without requiring H2O2, horseradish peroxidase, or oxygen Mus musculus C57BL/6 resorufin + acetate
-
 ?

Synonyms

Synonyms Comment Organism
CES
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Mus musculus

General Information

General Information Comment Organism
evolution CES belongs to the serine hydrolase family Mus musculus